Ubiquitin-mediated Proteolysis Pathway

Preferred Label : Ubiquitin-mediated Proteolysis Pathway;

NCIt related terms : Ubiquitin mediated proteolysis;

Alternative definition : KEGG: Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.;

KEGG ID : hsa04120;

Details

Origin ID

C38881;

UMLS CUI

C1519749;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- (E3-Independent) E2 Ubiquitin-Conjugating Enzyme [NCIt concept]
- Autoimmune Regulator [NCIt concept]
- Cullin-1 [NCIt concept]
- Cullin-2 [NCIt concept]
- Cullin-3 [NCIt concept]
- Cullin-4A [NCIt concept]
- Cullin-4B [NCIt concept]
- Cullin-5 [NCIt concept]
- DET1 Homolog [NCIt concept]
- DNA Damage-Binding Protein 1 [NCIt concept]
- DNA Damage-Binding Protein 2 [NCIt concept]
- DNA Excision Repair Protein ERCC-8 [NCIt concept]
- E3 SUMO-Protein Ligase PIAS1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CHIP [NCIt concept]
- E3 Ubiquitin-Protein Ligase COP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase FANCL [NCIt concept]
- E3 Ubiquitin-Protein Ligase HERC2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase HUWE1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Itchy Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Midline-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Parkin [NCIt concept]
- E3 Ubiquitin-Protein Ligase RBX1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM37 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIP12 [NCIt concept]
- E3 Ubiquitin-Protein Ligase UBR5 [NCIt concept]
- Elongin-C [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- F-Box/WD Repeat-Containing Protein 7 [NCIt concept]
- Fizzy-Related Protein Homolog [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2 [NCIt concept]
- NEDD8-Activating Enzyme E1 Catalytic Subunit [NCIt concept]
- Protein PML [NCIt concept]
- S-Phase Kinase-Associated Protein 1 [NCIt concept]
- S-Phase Kinase-Associated Protein 2 [NCIt concept]
- SUMO-Activating Enzyme Subunit 1 [NCIt concept]
- SUMO-Activating Enzyme Subunit 2 [NCIt concept]
- SUMO-Conjugating Enzyme UBC9 [NCIt concept]
- Suppressor of Cytokine Signaling 1 [NCIt concept]
- Suppressor of Cytokine Signaling 3 [NCIt concept]
- Ubiquitin Conjugation Factor E4 B [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 A [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 C [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 D2 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 L3 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 N [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 R1 [NCIt concept]
- Ubiquitin-Like Modifier-Activating Enzyme 1 [NCIt concept]
- Ubiquitin-Protein Ligase E3A [NCIt concept]
- Von Hippel-Lindau Disease Tumor Suppressor [NCIt concept]
pathway_has_gene_element
- AIRE wt Allele [NCIt concept]
- BTRC wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CDC34 wt Allele [NCIt concept]
- COP1 wt Allele [NCIt concept]
- CUL1 wt Allele [NCIt concept]
- CUL2 wt Allele [NCIt concept]
- CUL3 wt Allele [NCIt concept]
- CUL4A wt Allele [NCIt concept]
- CUL4B wt Allele [NCIt concept]
- CUL5 wt Allele [NCIt concept]
- DDB1 wt Allele [NCIt concept]
- DDB2 wt Allele [NCIt concept]
- DET1 wt Allele [NCIt concept]
- ELOC wt Allele [NCIt concept]
- FANCL wt Allele [NCIt concept]
- FBXW7 wt Allele [NCIt concept]
- FZR1 wt Allele [NCIt concept]
- HERC2 wt Allele [NCIt concept]
- HUWE1 wt Allele [NCIt concept]
- ITCH wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MID1 wt Allele [NCIt concept]
- PIAS1 wt Allele [NCIt concept]
- PML wt Allele [NCIt concept]
- PRKN wt Allele [NCIt concept]
- RBX1 wt Allele [NCIt concept]
- SAE1 wt Allele [NCIt concept]
- SKP1 wt Allele [NCIt concept]
- SKP2 wt Allele [NCIt concept]
- SMURF2 wt Allele [NCIt concept]
- SOCS1 wt Allele [NCIt concept]
- SOCS3 wt Allele [NCIt concept]
- STUB1 wt Allele [NCIt concept]
- TRIM37 wt Allele [NCIt concept]
- TRIP12 wt Allele [NCIt concept]
- UBA1 wt Allele [NCIt concept]
- UBA2 wt Allele [NCIt concept]
- UBA3 wt Allele [NCIt concept]
- UBE2A wt Allele [NCIt concept]
- UBE2C wt Allele [NCIt concept]
- UBE2D2 wt Allele [NCIt concept]
- UBE2I wt Allele [NCIt concept]
- UBE2L3 wt Allele [NCIt concept]
- UBE2N wt Allele [NCIt concept]
- UBE2O wt Allele [NCIt concept]
- UBE3A wt Allele [NCIt concept]
- UBE4B wt Allele [NCIt concept]
- UBR5 wt Allele [NCIt concept]
- VHL wt Allele [NCIt concept]
- WWP1 wt Allele [NCIt concept]
- WWP2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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