(E3-Independent) E2 Ubiquitin-Conjugating Enzyme

Preferred Label : (E3-Independent) E2 Ubiquitin-Conjugating Enzyme;

NCIt synonyms : E2/E3 Hybrid Ubiquitin-Protein Ligase UBE2O; Ubiquitin-Protein Ligase O; Ubiquitin-Conjugating Enzyme E2 O; UBE2O; EC 2.3.2.24; Ubiquitin Carrier Protein O; Ubiquitin Conjugating Enzyme E2O; Ubiquitin-Conjugating Enzyme E2-230K; Ubiquitin-Conjugating Enzyme E2 of 230 kDa; Ubiquitin-Conjugating Enzyme E2O;

NCIt definition : (E3-independent) E2 ubiquitin-conjugating enzyme (1292 aa, 141 kDa) is encoded by the human UBE2O gene. This protein is involved in the monoubiquitination of target proteins.;

NCIt note : (E3-independent) E2 ubiquitin-conjugating enzyme possesses E2 and E3 ligase activities. (UniProt);

Details

Origin ID

C150023;

UMLS CUI

C3851786;

Automatic exact mappings (from CISMeF team)
- Ubiquitin-conjugating enzyme e2 o [OMIM gene]
OMIM relation
- Ubiquitin-conjugating enzyme e2 o [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- UBE2O protein, human [MeSH concept]
- UBE2O protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- UBE2O Gene [NCIt concept]
- Ubiquitin-Conjugating Enzyme Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Skeletal Muscle Tissue [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intracellular Transport [NCIt concept]
- Monoubiquitination [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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