Preferred Label : Ubiquitination;
NCIt synonyms : Ubiquitilation; Ubiquitinoylation; Protein Ubiquitination; Ubiquitylation;
NCIt definition : Ubiquitin is a family of widely distributed proteins found in all eukaryotes that
contain a highly conserved sequence of 76 amino acids identical in organisms from
humans to insects. It participates in diverse cellular functions by conjugation to
other proteins through its carboxy terminus. Ubiquitination is associated with many
highly regulated biological events including protein degradation, chromatin remodelling,
heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus
assembly, apoptosis, signal transduction, transcriptional activation, biological clocks,
receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives
of many proteins by targeting them for degradation. Newly discovered families of ubiquitination
and deubiquitination enzymes participate in these processes. Ubiquitination enzymes
may provide new therapeutic targets and ways of intervention in many human diseases.;
Origin ID : C19358;
UMLS CUI : C1519751;
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
Semantic type(s)
UMLS correspondences (same concept)
biological_process_involves_gene_product
biological_process_is_part_of_process
process_involves_gene