CRL4-CRBN E3 Ubiquitin Ligase Complex

Preferred Label : CRL4-CRBN E3 Ubiquitin Ligase Complex;

NCIt synonyms : CRL4(CRBN) Ubiquitin Ligase Complex; CRL4-CRBN; CRL4CRBN; CUL4-CRBN E3 Ubiquitin Ligase; CRL4-CRBN E3 Ubiquitin Ligase; CRL4(CRBN);

NCIt definition : A DCX (DDB1-CUL4-X-box) ubiquitin protein ligase complex that is composed of protein cereblon (CRBN), cullin-4A (CUL4A) or cullin-4B (CUL4B), DNA damage-binding protein 1 (DDB1) and E3 ubiquitin-protein ligase RBX1. This enzyme complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The CRBN moiety regulates substrate recognition.;

Détails

Origin ID

C212947;

concept_is_in_subset
- Pediatric Oncology Target Cell Lineage Determinant Terminology [NCIt concept]
gene_encodes_gene_product
- Ubiquitin-Activating Enzyme Gene [NCIt concept]
gene_product_has_biochemical_function
- Ligase [NCIt concept]
gene_product_has_chemical_classification
- Protein or Riboprotein Complex [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitination [NCIt concept]
has_gene_product_element
- Protein Cereblon [NCIt concept]

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