Ubiquitin-Activating Enzyme Gene

Preferred Label : Ubiquitin-Activating Enzyme Gene;

NCIt synonyms : Ubiquitin Ligase Gene; E1 Ubiquitin-Activating Enzyme Gene;

NCIt definition : Genes encoding enzymes that catalyze the first step in the ubiquitination reaction via the ligation of the C-terminal lysine of ubiquitin to the E1 enzyme in an ATP-dependent reaction.;

NCIt note : The IUBMB has recategorized E2 ubiquitin-conjugating enzymes and E3 ubiquitin-protein ligases as transferases (EC 2). Thus, E1, E2 and E3 enzymes may be considered part of a ubiquitin ligase complex, but only E1 enzymes are categorized as ligases (EC 6).;

NCI Metathesaurus CUI : CL520265;

Details

Origin ID

C26066;

UMLS CUI

C1336849;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
Validated automatic mappings to NTBT
- ubiquitin-activating enzymes [MeSH Descriptor]
gene_encodes_gene_product
- Linear Ubiquitin Chain Assembly Complex [NCIt concept]
- Ubiquitin Protein Ligase [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients