" /> Cullin-RING E3 Ubiquitin Ligase Complex - CISMeF





Preferred Label : Cullin-RING E3 Ubiquitin Ligase Complex;

NCIt synonyms : CRL; Cullin-Ring E3 Ligase; Cullin-RING E3 Ubiquitin Ligase; Cullin-RING-Based E3 Ubiquitin-Protein Ligase Complex;

NCIt definition : An enzyme complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is comprised of four core components, a cullin protein that serves as a scaffold, a substrate receptor that recognizes the target protein, an adaptor protein that bridges the substrate receptor to the cullin and a RING finger E3 ubiquitin-protein ligase which binds to the cullin protein, recruits an E2 ubiquitin conjugating enzyme to the complex and promotes the transfer of ubiquitin from the E2 enzyme to the substrate.;

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17/08/2025


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