" /> Cullin-RING E3 Ubiquitin Ligase Complex - CISMeF





Preferred Label : Cullin-RING E3 Ubiquitin Ligase Complex;

NCIt synonyms : CRL; Cullin-Ring E3 Ligase; Cullin-RING E3 Ubiquitin Ligase; Cullin-RING-Based E3 Ubiquitin-Protein Ligase Complex;

NCIt definition : An enzyme complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is comprised of four core components, a cullin protein that serves as a scaffold, a substrate receptor that recognizes the target protein, an adaptor protein that bridges the substrate receptor to the cullin and a RING finger E3 ubiquitin-protein ligase which binds to the cullin protein, recruits an E2 ubiquitin conjugating enzyme to the complex and promotes the transfer of ubiquitin from the E2 enzyme to the substrate.;

Détails


Position du mot-clé dans l'(les) arborescence(s) : arborescence

Vous pouvez consulter :


Nous contacter.
28/07/2025


[Accueil] [Haut de page]

© CHU de Rouen. Toute utilisation partielle ou totale de ce document doit mentionner la source.