TNF Receptor-Associated Factor 6

Preferred Label : TNF Receptor-Associated Factor 6;

NCIt synonyms : TRAF6; Interleukin 1 Signal Transducer; E3 Ubiquitin-Protein Ligase TRAF6; Interleukin-1 Signal Transducer; EC 6.3.2.-, Formerly; RING Finger Protein 85; TNF Receptor-Associated Factor-6; EC 2.3.2.27;

NCIt definition : TNF receptor-associated factor 6 (522 aa, 60 kDa) is encoded by the human TRAF6 gene. This protein is involved in polyubiquitination of protein substrates.;

NCIt note : TNF receptor-associated factor 6 contains a MATH domain, a RING-type zinc finger, 2 TRAF-type zinc fingers, and a coiled coil domain that mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains.;

Details

Origin ID

C30125;

UMLS CUI

C4076919;

Currated CISMeF NLP mapping
- TNF Receptor-Associated factor 6 [MeSH Descriptor]
- TNF Receptor-Associated factor 6 [MeSH concept]
OMIM relation
- Tnf receptor-associated factor 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- TNF Receptor-Associated factor 6 [MeSH concept]
- TNF Receptor-Associated factor 6 [MeSH Descriptor]
- Tifab protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- TRAF6 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- TRAF Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- B-Cell Immune Response Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- Bone Remodeling Pathway [NCIt concept]
- CD40/CD40L Signaling Pathway [NCIt concept]
- CD40L Signaling Pathway [NCIt concept]
- Canonical NF-kappaB Signaling Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- IL1-Mediated Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- RELA Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Regulation of p38-alpha and p38-beta Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD4+ T Cells [NCIt concept]
- T-Cell Receptor Signaling Pathway in Naive CD8+ T Cells [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Inflammatory Response [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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