Ring Finger Domain

Preferred Label : Ring Finger Domain;

NCIt synonyms : Ring Finger Motif; Ring-Type Zinc Finger Domain; Ring Finger;

NCIt definition : The RING finger is a specialized type of Zn-finger consisting of 40 to 60 residues, which has the consensus sequence CX2CX(9-39)CX(1-3)HX(2-3)C/HX2CX(4-48)CX2C, that binds two atoms of zinc, and is involved in mediating protein-protein interactions. The RING domain mediates the interaction with the appropriate E2 enzyme. Unlike HECT E3 enzymes that form a thiol-ester with ubiquitin, RING fingers likely mediate ubiquitination by facilitating the direct transfer of ubiquitin from E2 enzyme to lysine residues on the target substrate.;

Details

Origin ID

C13746;

UMLS CUI

C1521759;

Associated anatomy of gene products
- E3 Ubiquitin-Protein Ligase AMFR [NCIt concept]
Automatic exact mappings (from CISMeF team)
- trigger finger disorder [MeSH Descriptor]
Currated CISMeF NLP mapping
- Finger fourth [LOINC System]
- RING finger domains [MeSH concept]
- Ring finger [ICD-11 Extension code]
- Ring finger [FMA entity]
- Ring finger structure (body structure) [SNOMED CT concept]
- manual digit 4 [UBERON concept]
- ring finger [Radlex concept]
- ring finger domains [MeSH Descriptor]
- ring finger, nos [SNOMED Notion]
False automatic mappings
- Ring finger [ICHI extension code]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- RING finger domains [MeSH concept]
- ring finger domains [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- 43 kDa Receptor-Associated Protein of the Synapse [NCIt concept]
- BRCA1-Associated RING Domain Protein 1 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 1 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 5 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 7 [NCIt concept]
- E3 SUMO-Protein Ligase NSE2 [NCIt concept]
- E3 SUMO-Protein Ligase PIAS3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase ARIH1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Arkadia [NCIt concept]
- E3 Ubiquitin-Protein Ligase BRE1A [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- E3 Ubiquitin-Protein Ligase CCNB1IP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CHFR [NCIt concept]
- E3 Ubiquitin-Protein Ligase COP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase DTX1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MARCH9 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Makorin-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Midline-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase NEURL1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Parkin [NCIt concept]
- E3 Ubiquitin-Protein Ligase Pellino Homolog 3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RAD18 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RFWD3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RING2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF130 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF139 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF146 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF213 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF216 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF31 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF43 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAF7 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAIP [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM13 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM21 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM23 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM37 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM38 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM56 [NCIt concept]
- E3 Ubiquitin-Protein Ligase UHRF1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]
- E3 Ubiquitin-Protein Ligase ZNRF3 [NCIt concept]
- E3 Ubiquitin/ISG15 Ligase TRIM25 [NCIt concept]
- Histone-Lysine N-Methyltransferase 2C [NCIt concept]
- IAP Family Protein [NCIt concept]
- Interferon Regulatory Factor 2-Binding Protein 2 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Polycomb Complex Protein BMI-1 [NCIt concept]
- Protein PML [NCIt concept]
- RING Finger Protein 11 [NCIt concept]
- RanBP-Type and C3HC4-Type Zinc Finger-Containing Protein 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TNF Receptor-Associated Factor 4 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Intermediary Factor 1-Alpha [NCIt concept]
- Transcriptional Intermediary Factor 1-Beta [NCIt concept]
- Vacuolar Protein Sorting-Associated Protein 18 [NCIt concept]
- Zinc-Finger Protein RFP [NCIt concept]

Keyword's position in hierarchy(ies) :

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