E3 Ubiquitin-Protein Ligase AMFR

Preferred Label : E3 Ubiquitin-Protein Ligase AMFR;

NCIt synonyms : AMF Receptor; RNF45; AMFR; AMFR Protein; GP78; AMF-R; Autocrine Mobility Factor Receptor; RING Finger Protein 45; Autocrine Motility Factor Receptor; EC 2.3.2.36;

NCIt definition : E3 ubiquitin-protein ligase AMFR (643 aa, 75 kDa) is encoded by the human AMFR gene. This protein plays a role in endoplasmic reticulum-associated degradation, protein polyubiquitination, and autocrine motility factor binding.;

NCIt note : Secreted by tumor cells, autocrine motility factor stimulates tumor motility. Its glycoprotein receptor, Autocrine Mobility Factor Receptor, has some homology to p53. In normal fibroblasts, receptor expression appears to be regulated by cell-cell contact. The level of expression is associated with the pathologic stage and grade of tumor penetration. Positive AMFR expression on tumor cells correlates with poor prognosis in bladder cancer. (from OMIM 603243 and NCI);

Details

Origin ID

C17577;

UMLS CUI

C1869251;

OMIM relation
- Autocrine motility factor receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- AMFR protein, human [MeSH concept]
- AMFR protein, human [MeSH Supplementary Concept]
- receptors, autocrine motility factor [MeSH concept]
- receptors, autocrine motility factor [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- AMFR Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Plasma Membrane [NCIt concept]
- Ring Finger Domain [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_malfunction_associated_with_disease
- Bladder Carcinoma [NCIt concept]
- Gastric Carcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Motility [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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