Ubiquitinated Protein Degradation

Preferred Label : Ubiquitinated Protein Degradation;

NCIt synonyms : Removal of Protein-Ubiquitin Conjugate;

NCIt definition : Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction.;

Details

Origin ID

C21243;

UMLS CUI

C1519750;

Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_involves_gene_product
- (E3-Independent) E2 Ubiquitin-Conjugating Enzyme [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 11 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 2 [NCIt concept]
- 26S Proteasome Non-ATPase Regulatory Subunit 3 [NCIt concept]
- 26S Proteasome Regulatory Subunit 6A [NCIt concept]
- 26S Proteasome Regulatory Subunit 7 [NCIt concept]
- Ankyrin Repeat and SOCS Box Protein 2 [NCIt concept]
- Ataxin-3 [NCIt concept]
- BRCA1-Associated RING Domain Protein 1 [NCIt concept]
- BTB/POZ Domain-Containing Adapter for CUL3-Mediated RhoA Degradation Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 2 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 3 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 6 [NCIt concept]
- Baculoviral IAP Repeat-Containing Protein 7 [NCIt concept]
- Breast Cancer Type 1 Susceptibility Protein [NCIt concept]
- DCN1-Like Protein 1 [NCIt concept]
- DET1 Homolog [NCIt concept]
- DET1- and DDB1-Associated Protein 1 [NCIt concept]
- Denticleless Protein Homolog [NCIt concept]
- E2 Ubiquitin-Conjugating Enzyme [NCIt concept]
- E3 Ubiquitin Ligase TRAF3IP2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase AMFR [NCIt concept]
- E3 Ubiquitin-Protein Ligase ARIH1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Arkadia [NCIt concept]
- E3 Ubiquitin-Protein Ligase BRE1A [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- E3 Ubiquitin-Protein Ligase CCNB1IP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CHFR [NCIt concept]
- E3 Ubiquitin-Protein Ligase COP1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase DTX1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase FANCL [NCIt concept]
- E3 Ubiquitin-Protein Ligase HACE1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase HERC2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase HUWE1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Itchy Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase MARCH9 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MIB1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase MYCBP2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Makorin-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Midline-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase NEDD4 [NCIt concept]
- E3 Ubiquitin-Protein Ligase NEURL1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Parkin [NCIt concept]
- E3 Ubiquitin-Protein Ligase Pellino Homolog 3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RAD18 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RBX1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RFWD3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RING2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF130 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF139 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF146 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF213 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF216 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF31 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF43 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SIAH2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase SMURF2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAF7 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRAIP [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM13 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM21 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM23 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM33 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM36 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM37 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM38 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM56 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM63 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIP12 [NCIt concept]
- E3 Ubiquitin-Protein Ligase UBR5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase UHRF1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase XIAP [NCIt concept]
- E3 Ubiquitin-Protein Ligase ZNRF3 [NCIt concept]
- E3 Ubiquitin-Protein Transferase [NCIt concept]
- E3 Ubiquitin/ISG15 Ligase TRIM25 [NCIt concept]
- F-Box Only Protein 11 [NCIt concept]
- F-Box Only Protein 3 [NCIt concept]
- F-Box Only Protein 31 [NCIt concept]
- F-Box/LRR-Repeat Protein 18 [NCIt concept]
- F-Box/LRR-Repeat Protein 19 [NCIt concept]
- F-Box/LRR-Repeat Protein 4 [NCIt concept]
- FAS-Associated Factor 2 [NCIt concept]
- Glucose-Induced Degradation Protein 4 Homolog [NCIt concept]
- Helicase-Like Transcription Factor [NCIt concept]
- Kelch-Like Protein 24 [NCIt concept]
- Kelch-Like Protein 40 [NCIt concept]
- Kelch-Like Protein 42 [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2A [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP1 [NCIt concept]
- NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2 [NCIt concept]
- NEDD8 [NCIt concept]
- NEDD8 Activating Enzyme [NCIt concept]
- NEDD8-Activating Enzyme E1 Catalytic Subunit [NCIt concept]
- NEDD8-Activating Enzyme E1 Regulatory Subunit [NCIt concept]
- Probable E3 Ubiquitin-Protein Ligase DTX2 [NCIt concept]
- Proteasomal Ubiquitin Receptor ADRM1 [NCIt concept]
- Proteasome Activator Complex Subunit 3 [NCIt concept]
- Proteasome Subunit Alpha Type-5 [NCIt concept]
- Proteasome Subunit Beta Type-10 [NCIt concept]
- Proteasome Subunit Beta Type-5 [NCIt concept]
- Proteasome Subunit Beta Type-8 [NCIt concept]
- Protein Cereblon [NCIt concept]
- Protein Fem-1 Homolog C [NCIt concept]
- Protein Yippee-Like 5 [NCIt concept]
- RING Finger Protein 11 [NCIt concept]
- RanBP-Type and C3HC4-Type Zinc Finger-Containing Protein 1 [NCIt concept]
- S-Phase Kinase-Associated Protein 1 [NCIt concept]
- Synphilin-1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Intermediary Factor 1-Alpha [NCIt concept]
- Transitional Endoplasmic Reticulum ATPase [NCIt concept]
- Tripartite Motif-Containing Protein 16 [NCIt concept]
- Tripartite Motif-Containing Protein 5 [NCIt concept]
- UV Excision Repair Protein RAD23 Homolog A [NCIt concept]
- UV Excision Repair Protein RAD23 Homolog B [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase 14 [NCIt concept]
- Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L5 [NCIt concept]
- Ubiquitin Conjugation Factor E4 B [NCIt concept]
- Ubiquitin D [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 A [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 C [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 D2 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 L3 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 N [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 R1 [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 T [NCIt concept]
- Ubiquitin-Protein Ligase E3A [NCIt concept]
- V(D)J Recombination-Activating Protein 1 [NCIt concept]
- Zinc-Finger Protein RFP [NCIt concept]
biological_process_is_part_of_process
- Biochemical Process [NCIt concept]
process_involves_gene
- ADRM1 Gene [NCIt concept]
- ADRM1 wt Allele [NCIt concept]
- AMFR Gene [NCIt concept]
- AMFR wt Allele [NCIt concept]
- ARIH1 Gene [NCIt concept]
- ARIH1 wt Allele [NCIt concept]
- ASB2 Gene [NCIt concept]
- ASB2 wt Allele [NCIt concept]
- ATXN3 Gene [NCIt concept]
- ATXN3 wt Allele [NCIt concept]
- BARD1 Gene [NCIt concept]
- BARD1 wt Allele [NCIt concept]
- BIRC2 Gene [NCIt concept]
- BIRC2 wt Allele [NCIt concept]
- BIRC3 Gene [NCIt concept]
- BIRC3 wt Allele [NCIt concept]
- BIRC6 Gene [NCIt concept]
- BIRC6 wt Allele [NCIt concept]
- BIRC7 Gene [NCIt concept]
- BIRC7 wt Allele [NCIt concept]
- BRCA1 Gene [NCIt concept]
- BRCA1 wt Allele [NCIt concept]
- CBL Gene [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB Gene [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC Gene [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CCNB1IP1 Gene [NCIt concept]
- CCNB1IP1 wt Allele [NCIt concept]
- CDC34 Gene [NCIt concept]
- CDC34 wt Allele [NCIt concept]
- CHFR Gene [NCIt concept]
- CHFR wt Allele [NCIt concept]
- COP1 Gene [NCIt concept]
- COP1 wt Allele [NCIt concept]
- DDA1 Gene [NCIt concept]
- DDA1 wt Allele [NCIt concept]
- DET1 Gene [NCIt concept]
- DET1 wt Allele [NCIt concept]
- DTL Gene [NCIt concept]
- DTL wt Allele [NCIt concept]
- DTX1 Gene [NCIt concept]
- DTX1 wt Allele [NCIt concept]
- DTX2 Gene [NCIt concept]
- DTX2 wt Allele [NCIt concept]
- FAF2 Gene [NCIt concept]
- FAF2 wt Allele [NCIt concept]
- FANCL Gene [NCIt concept]
- FANCL wt Allele [NCIt concept]
- FBXL18 Gene [NCIt concept]
- FBXL18 wt Allele [NCIt concept]
- FBXL19 Gene [NCIt concept]
- FBXL19 wt Allele [NCIt concept]
- FBXL4 Gene [NCIt concept]
- FBXL4 wt Allele [NCIt concept]
- FBXO11 Gene [NCIt concept]
- FBXO11 wt Allele [NCIt concept]
- FBXO3 Gene [NCIt concept]
- FBXO3 wt Allele [NCIt concept]
- FBXO31 Gene [NCIt concept]
- FBXO31 wt Allele [NCIt concept]
- GID4 Gene [NCIt concept]
- GID4 wt Allele [NCIt concept]
- HACE1 Gene [NCIt concept]
- HACE1 wt Allele [NCIt concept]
- HERC2 Gene [NCIt concept]
- HERC2 wt Allele [NCIt concept]
- HLTF Gene [NCIt concept]
- HLTF wt Allele [NCIt concept]
- HUWE1 Gene [NCIt concept]
- HUWE1 wt Allele [NCIt concept]
- ITCH Gene [NCIt concept]
- ITCH wt Allele [NCIt concept]
- KEAP1 Gene [NCIt concept]
- KEAP1 wt Allele [NCIt concept]
- KLHL24 Gene [NCIt concept]
- KLHL24 wt Allele [NCIt concept]
- KLHL40 Gene [NCIt concept]
- KLHL40 wt Allele [NCIt concept]
- KLHL42 Gene [NCIt concept]
- KLHL42 wt Allele [NCIt concept]
- MAD2L1 Gene [NCIt concept]
- MAD2L1 wt Allele [NCIt concept]
- MARCHF9 Gene [NCIt concept]
- MARCHF9 wt Allele [NCIt concept]
- MDM2 Gene [NCIt concept]
- MDM2 SNP309 Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MIB1 Gene [NCIt concept]
- MIB1 wt Allele [NCIt concept]
- MID1 Gene [NCIt concept]
- MID1 wt Allele [NCIt concept]
- MKRN1 Gene [NCIt concept]
- MKRN1 wt Allele [NCIt concept]
- MYCBP2 Gene [NCIt concept]
- MYCBP2 wt Allele [NCIt concept]
- NAE1 Gene [NCIt concept]
- NAE1 wt Allele [NCIt concept]
- NEDD4 Gene [NCIt concept]
- NEDD4 wt Allele [NCIt concept]
- NEDD8 Gene [NCIt concept]
- NEDD8 wt Allele [NCIt concept]
- NEURL1 Gene [NCIt concept]
- NEURL1 wt Allele [NCIt concept]
- PELI3 Gene [NCIt concept]
- PELI3 wt Allele [NCIt concept]
- PRKN Gene [NCIt concept]
- PRKN wt Allele [NCIt concept]
- PSMA5 Gene [NCIt concept]
- PSMA5 wt Allele [NCIt concept]
- PSMB10 Gene [NCIt concept]
- PSMB10 wt Allele [NCIt concept]
- PSMB5 Gene [NCIt concept]
- PSMB5 wt Allele [NCIt concept]
- PSMB8 Gene [NCIt concept]
- PSMB8 wt Allele [NCIt concept]
- PSMC2 Gene [NCIt concept]
- PSMC2 wt Allele [NCIt concept]
- PSMC3 Gene [NCIt concept]
- PSMC3 wt Allele [NCIt concept]
- PSMD10 Gene [NCIt concept]
- PSMD10 wt Allele [NCIt concept]
- PSMD11 Gene [NCIt concept]
- PSMD11 wt Allele [NCIt concept]
- PSMD2 Gene [NCIt concept]
- PSMD2 wt Allele [NCIt concept]
- PSMD3 Gene [NCIt concept]
- PSMD3 wt Allele [NCIt concept]
- PSME3 Gene [NCIt concept]
- PSME3 wt Allele [NCIt concept]
- RAD18 Gene [NCIt concept]
- RAD18 wt Allele [NCIt concept]
- RAD23A Gene [NCIt concept]
- RAD23A wt Allele [NCIt concept]
- RAD23B Gene [NCIt concept]
- RAD23B wt Allele [NCIt concept]
- RAG1 Gene [NCIt concept]
- RAG1 wt Allele [NCIt concept]
- RBCK1 Gene [NCIt concept]
- RBCK1 wt Allele [NCIt concept]
- RBX1 Gene [NCIt concept]
- RBX1 wt Allele [NCIt concept]
- RFWD3 Gene [NCIt concept]
- RFWD3 wt Allele [NCIt concept]
- RNF111 Gene [NCIt concept]
- RNF111 wt Allele [NCIt concept]
- RNF130 Gene [NCIt concept]
- RNF130 wt Allele [NCIt concept]
- RNF139 Gene [NCIt concept]
- RNF139 wt Allele [NCIt concept]
- RNF146 Gene [NCIt concept]
- RNF146 wt Allele [NCIt concept]
- RNF2 Gene [NCIt concept]
- RNF2 wt Allele [NCIt concept]
- RNF20 Gene [NCIt concept]
- RNF20 wt Allele [NCIt concept]
- RNF216 Gene [NCIt concept]
- RNF216 wt Allele [NCIt concept]
- RNF31 Gene [NCIt concept]
- RNF31 wt Allele [NCIt concept]
- RNF43 Gene [NCIt concept]
- RNF43 wt Allele [NCIt concept]
- RNF5 Gene [NCIt concept]
- RNF5 wt Allele [NCIt concept]
- SIAH2 Gene [NCIt concept]
- SIAH2 wt Allele [NCIt concept]
- SKP1 Gene [NCIt concept]
- SKP1 wt Allele [NCIt concept]
- SMURF2 Gene [NCIt concept]
- SMURF2 wt Allele [NCIt concept]
- SNCAIP Gene [NCIt concept]
- SNCAIP wt Allele [NCIt concept]
- TNFAIP1 Gene [NCIt concept]
- TNFAIP1 wt Allele [NCIt concept]
- TRAF2 Gene [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF3 Gene [NCIt concept]
- TRAF3 wt Allele [NCIt concept]
- TRAF3IP2 Gene [NCIt concept]
- TRAF3IP2 wt Allele [NCIt concept]
- TRAF6 Gene [NCIt concept]
- TRAF6 wt Allele [NCIt concept]
- TRAF7 Gene [NCIt concept]
- TRAF7 wt Allele [NCIt concept]
- TRAIP Gene [NCIt concept]
- TRAIP wt Allele [NCIt concept]
- TRIM13 Gene [NCIt concept]
- TRIM13 wt Allele [NCIt concept]
- TRIM21 Gene [NCIt concept]
- TRIM21 wt Allele [NCIt concept]
- TRIM23 Gene [NCIt concept]
- TRIM23 wt Allele [NCIt concept]
- TRIM24 Gene [NCIt concept]
- TRIM24 wt Allele [NCIt concept]
- TRIM25 Gene [NCIt concept]
- TRIM25 wt Allele [NCIt concept]
- TRIM27 Gene [NCIt concept]
- TRIM27 wt Allele [NCIt concept]
- TRIM33 Gene [NCIt concept]
- TRIM33 wt Allele [NCIt concept]
- TRIM36 Gene [NCIt concept]
- TRIM36 wt Allele [NCIt concept]
- TRIM37 Gene [NCIt concept]
- TRIM37 wt Allele [NCIt concept]
- TRIM38 Gene [NCIt concept]
- TRIM38 wt Allele [NCIt concept]
- TRIM5 Gene [NCIt concept]
- TRIM5 wt Allele [NCIt concept]
- TRIM56 Gene [NCIt concept]
- TRIM56 wt Allele [NCIt concept]
- TRIM63 Gene [NCIt concept]
- TRIM63 wt Allele [NCIt concept]
- TRIP12 Gene [NCIt concept]
- TRIP12 wt Allele [NCIt concept]
- UBA3 Gene [NCIt concept]
- UBA3 wt Allele [NCIt concept]
- UBE2A Gene [NCIt concept]
- UBE2A wt Allele [NCIt concept]
- UBE2C Gene [NCIt concept]
- UBE2C wt Allele [NCIt concept]
- UBE2D2 Gene [NCIt concept]
- UBE2D2 wt Allele [NCIt concept]
- UBE2L3 Gene [NCIt concept]
- UBE2L3 wt Allele [NCIt concept]
- UBE2N Gene [NCIt concept]
- UBE2N wt Allele [NCIt concept]
- UBE2O Gene [NCIt concept]
- UBE2O wt Allele [NCIt concept]
- UBE2T Gene [NCIt concept]
- UBE2T wt Allele [NCIt concept]
- UBE3A Gene [NCIt concept]
- UBE3A wt Allele [NCIt concept]
- UBE4B Gene [NCIt concept]
- UBE4B wt Allele [NCIt concept]
- UBR5 Gene [NCIt concept]
- UBR5 wt Allele [NCIt concept]
- UCHL5 Gene [NCIt concept]
- UCHL5 wt Allele [NCIt concept]
- UHRF1 Gene [NCIt concept]
- UHRF1 wt Allele [NCIt concept]
- USP14 Gene [NCIt concept]
- USP14 wt Allele [NCIt concept]
- Ubiquitin-Conjugating Enzyme Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
- VCP Gene [NCIt concept]
- VCP wt Allele [NCIt concept]
- WWP1 Gene [NCIt concept]
- WWP1 wt Allele [NCIt concept]
- WWP2 Gene [NCIt concept]
- WWP2 wt Allele [NCIt concept]
- XIAP Gene [NCIt concept]
- XIAP wt Allele [NCIt concept]
- YPEL5 Gene [NCIt concept]
- YPEL5 wt Allele [NCIt concept]
- ZNRF3 Gene [NCIt concept]
- ZNRF3 wt Allele [NCIt concept]

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