E3 Ubiquitin-Protein Ligase ARIH1

Preferred Label : E3 Ubiquitin-Protein Ligase ARIH1;

NCIt synonyms : Ubiquitin-Conjugating Enzyme E2-Binding Protein 1; Protein Ariadne-1 Homolog; MOP-6; ARI-1; UbcM4-Interacting Protein; UbcH7-Binding Protein; Monocyte Protein 6; H7-AP2; EC 2.3.2.31;

NCIt definition : E3 ubiquitin-protein ligase ARIH1 (557 aa, 64 kDa) is encoded by the human ARIH1 gene. This protein is involved in protein ubiquitination.;

NCIt note : E3 ubiquitin-protein ligase ARIH1 is autoinhibited by the ariadne domain, which binds to the second RING finger domain masking the active site. The autoinhibition is alleviated when the ariadne domain binds to neddylated cullin-RING ubiquitin ligase complexes. (UniProt);

NCI Metathesaurus CUI : CL521965;

Details

Origin ID

C134189;

UMLS CUI

C4522226;

Automatic exact mappings (from CISMeF team)
- Ariadne rbr e3 ubiquitin protein ligase 1 [OMIM gene]
- Neuronal pas domain protein 3 [OMIM gene]
OMIM relation
- Ariadne rbr e3 ubiquitin protein ligase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- ARIH1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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