NCIt definition : Human NEURL1 wild-type allele is located in the vicinity of 10q24.33 and is approximately
98 kb in length. This allele, which encodes E3 ubiquitin-protein ligase NEURL1 protein,
plays a role in the regulation of proteasome-mediated protein degradation. The gene
exhibits loss of heterozygosity in astrocytomas.;
NCIt note : The NEURL gene has been proposed to be involved in the determination of cell fate
in the developing central nervous system. It is a putative tumor suppressor gene in
astrocytomas.;