Monoubiquitination

Preferred Label : Monoubiquitination;

NCIt definition : The type of ubiquitin modification determines the functional consequences for the modified protein. Monoubiquitination does not serve as a proteasome targeting signal, but plays other distinct roles. Target proteins are monoubiquitinated on one or more lysine residues, which serve as a signal for intracellular sorting as well as endocytosis of cell-surface proteins. Monoubiquitination of cell-surface receptors serves as a signal to target them to lysosome, where they are degraded by lysosomal proteases. (From PMID and NCI);

Details

Origin ID

C21588;

UMLS CUI

C1513486;

Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_involves_gene_product
- (E3-Independent) E2 Ubiquitin-Conjugating Enzyme [NCIt concept]
- Centromere Protein X [NCIt concept]
- Denticleless Protein Homolog [NCIt concept]
- E3 Ubiquitin-Protein Ligase BRE1A [NCIt concept]
- E3 Ubiquitin-Protein Ligase Midline-1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase NEURL1 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RAD18 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RING2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RNF5 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM37 [NCIt concept]
- E3 Ubiquitin-Protein Ligase TRIM56 [NCIt concept]
- V(D)J Recombination-Activating Protein 1 [NCIt concept]
biological_process_is_part_of_process
- Post-Translational Regulation [NCIt concept]
- Protein Degradation Process [NCIt concept]
process_involves_gene
- CENPX Gene [NCIt concept]
- CENPX wt Allele [NCIt concept]
- DTL Gene [NCIt concept]
- DTL wt Allele [NCIt concept]
- MID1 Gene [NCIt concept]
- MID1 wt Allele [NCIt concept]
- NEURL1 Gene [NCIt concept]
- NEURL1 wt Allele [NCIt concept]
- RAD18 Gene [NCIt concept]
- RAD18 wt Allele [NCIt concept]
- RAG1 Gene [NCIt concept]
- RAG1 wt Allele [NCIt concept]
- RNF2 Gene [NCIt concept]
- RNF2 wt Allele [NCIt concept]
- RNF20 Gene [NCIt concept]
- RNF20 wt Allele [NCIt concept]
- RNF5 Gene [NCIt concept]
- RNF5 wt Allele [NCIt concept]
- TRIM37 Gene [NCIt concept]
- TRIM37 wt Allele [NCIt concept]
- TRIM56 Gene [NCIt concept]
- TRIM56 wt Allele [NCIt concept]
- UBE2O Gene [NCIt concept]
- UBE2O wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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