E3 Ubiquitin-Protein Ligase RING2

Preferred Label : E3 Ubiquitin-Protein Ligase RING2;

NCIt synonyms : RING Finger Protein 2; RING-Type E3 Ubiquitin Transferase RING2; RING Finger Protein BAP-1; Huntingtin-Interacting Protein 2-Interacting Protein 3; RING Finger Protein 1B; HIP2-Interacting Protein 3; EC 2.3.2.27; Protein DinG; RING1b; RNF2;

NCIt definition : E3 ubiquitin-protein ligase RING2 (336 aa, 38 kDa) is encoded by the human RNF2 gene. This protein is involved in both transcriptional repression and the monoubiquitination of lysine-119 of histone H2A.;

NCIt note : E3 ubiquitin-protein ligase RING2 is a member of a Polycomb group (PcG) protein complex that plays a role in transcriptional repression of genes during embryonic development and in imprinting.;

Details

Origin ID

C150306;

UMLS CUI

C1455461;

Automatic exact mappings (from CISMeF team)
- Ring finger protein 2 [OMIM gene]
- ring finger protein 2 [HGNC gene]
- ring finger protein 2 [ORDO Gene]
OMIM relation
- Ring finger protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RNF2 protein, human [MeSH concept]
- RNF2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- RNF2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_physical_part_of
- Polycomb Repressive Complex 1 [NCIt concept]
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Histone Modification [NCIt concept]
- Monoubiquitination [NCIt concept]
- Transcriptional Repression [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]

Keyword's position in hierarchy(ies) :

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