Polycomb Repressive Complex 1

Preferred Label : Polycomb Repressive Complex 1;

NCIt synonyms : PRC1;

NCIt definition : A protein complex that represses transcription by stimulating chromatin compaction, inhibiting elongation by RNA polymerase II and monoubiquitinating lysine-119 of histone H2A. Canonical Polycomb repressive complex 1 (PRC1) is comprised of a core complex containing one RING1, one PCGF, one CBX and one HPH family protein. Additionally, non-canonical forms of PRC1 exist and are more diverse; they may include only some members of the canonical core protein families as well as other proteins not found in the canonical complex. These complexes are involved in embryonic development and X chromosome inactivation.;

Details

Origin ID

C180427;

UMLS CUI

C5552842;

Automatic exact mappings (from CISMeF team)
- PRC1 complex [GO term]
- Protein regulating cytokinesis 1 [OMIM gene]
- polycomb repressive complex 1 [MeSH Descriptor]
- polycomb repressive complex 1 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
has_gene_product_element
- Chromobox Protein Homolog 2 [NCIt concept]
- E3 SUMO-Protein Ligase CBX4 [NCIt concept]
- E3 Ubiquitin-Protein Ligase RING2 [NCIt concept]
- Polycomb Complex Protein BMI-1 [NCIt concept]
- RING1 and YY1-Binding Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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