E3 SUMO-Protein Ligase CBX4

Preferred Label : E3 SUMO-Protein Ligase CBX4;

NCIt synonyms : Pc2; hPc2; Polycomb 2 Homolog; Chromobox Protein Homolog 4; CBX4; EC 2.3.2.-;

NCIt definition : E3 SUMO-protein ligase CBX4 (558 aa, 61 kDa) is encoded by the human CBX4 gene. This soluble, nuclear protein plays a role in repressing the expression of genes through SUMOylation of lysine 119 of histone H2A.;

NCIt note : Functions together with UBE2I ubiquitin conjugating enzyme, which together with CBX4, are components of the PRC1 complex. UBE2I is essential for nuclear architecture and chromosome segregation.;

Details

Origin ID

C73684;

UMLS CUI

C1571648;

False automatic mappings
- Prostate cancer, hereditary, 2 [OMIM Phenotype]
OMIM relation
- Chromobox 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CBX4 protein, human [MeSH Supplementary Concept]
- CBX4 protein, human [MeSH concept]
gene_encodes_gene_product
- CBX4 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gene Silencing Pathway [NCIt concept]
- Regulation of Retinoblastoma Protein Pathway [NCIt concept]
gene_product_is_physical_part_of
- Polycomb Repressive Complex 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Chromatin Remodeling [NCIt concept]
- Post-Translational Modification [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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