polycomb repressive complex 1

Preferred Label : polycomb repressive complex 1;

MeSH definition : A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.;

Registry Number MeSH : EC 6.3.2.19; EC 2.3.2.27;

Is substance : O;

UNII : EC 2.3.2.27;

Details

Origin ID

D063150;

UMLS CUI

C1335252;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Polycomb Repressive Complex 1 [NCIt concept]
- UBE3A wt Allele [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 C [NCIt concept]
- Ubiquitin-Conjugating Enzyme E2 D2 [NCIt concept]
- Ubiquitin-Protein Ligase E3A [NCIt concept]
Currated CISMeF NLP mapping
- Drosophila Polycomb Repressive Complex 1 [NCIt concept]
- PRC1 complex [GO term]
Record concept(s)
- polycomb repressive complex 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- BMI1 protein, human [MeSH Supplementary Concept]
- BMI1A protein, Arabidopsis [MeSH Supplementary Concept]
- BMI1B protein, Arabidopsis [MeSH Supplementary Concept]
- BMI1C protein, Arabidopsis [MeSH Supplementary Concept]
- Bmi1 protein, mouse [MeSH Supplementary Concept]
- Bmi1 protein, rat [MeSH Supplementary Concept]
- CBX2 protein, human [MeSH Supplementary Concept]
- CBX7 protein, human [MeSH Supplementary Concept]
- CBX7 protein, mouse [MeSH Supplementary Concept]
- CBX8 protein, human [MeSH Supplementary Concept]
- Cbx2 protein, mouse [MeSH Supplementary Concept]
- Cbx2 protein, rat [MeSH Supplementary Concept]
- Cbx4 protein, mouse [MeSH Supplementary Concept]
- Cbx4 protein, rat [MeSH Supplementary Concept]
- Cbx7 protein, rat [MeSH Supplementary Concept]
- Cbx8 protein, mouse [MeSH Supplementary Concept]
- Cbx8 protein, rat [MeSH Supplementary Concept]
- PCGF1 protein, human [MeSH Supplementary Concept]
- PCGF2 protein, human [MeSH Supplementary Concept]
- PCGF6 protein, human [MeSH Supplementary Concept]
- PHC1 protein, human [MeSH Supplementary Concept]
- PHC3 protein, human [MeSH Supplementary Concept]
- Pc protein, Drosophila [MeSH Supplementary Concept]
- Pcgf1 protein, mouse [MeSH Supplementary Concept]
- Pcgf1 protein, rat [MeSH Supplementary Concept]
- Pcgf6 protein, mouse [MeSH Supplementary Concept]
- Pcgf6 protein, rat [MeSH Supplementary Concept]
- Phc1 protein, mouse [MeSH Supplementary Concept]
- RING1 protein, human [MeSH Supplementary Concept]
- RING1b protein, arabidopsis [MeSH Supplementary Concept]
- RNF2 protein, human [MeSH Supplementary Concept]
- Ring1 protein, mouse [MeSH Supplementary Concept]
- Ring1 protein, rat [MeSH Supplementary Concept]
- Rnf2 protein, mouse [MeSH Supplementary Concept]
- Rnf2 protein, rat [MeSH Supplementary Concept]
- bmi1a protein, zebrafish [MeSH Supplementary Concept]
- cbx2 protein, zebrafish [MeSH Supplementary Concept]
- pcgf1 protein, danio rerio [MeSH Supplementary Concept]
- ph-d protein, Drosophila [MeSH Supplementary Concept]
- ph-p protein, Drosophila [MeSH Supplementary Concept]
- psc protein, drosophila [MeSH Supplementary Concept]
- sce protein, drosophila [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Drosophila Polycomb Repressive Complex 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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