Peroxisome Biogenesis Factor 2

Preferred Label : Peroxisome Biogenesis Factor 2;

NCIt synonyms : PEX2; Peroxisomal Membrane Protein 3; Peroxin-2; Peroxisome Assembly Factor 1; 35 kDa Peroxisomal Membrane Protein; EC 2.3.2.36; PAF-1; EC 2.3.2.27; Peroxisomal Biogenesis Factor 2; Peroxin 2; RING Finger Protein 72;

NCIt definition : Peroxisome biogenesis factor 2 (305 aa, 35 kDa) is encoded by the human PEX2 gene. This protein plays a role in both monoubiquitination of peroxisomal targeting signal 1 receptor (PEX5) and export of PEX5 from the proteosome to the cytoplasm.;

NCIt note : The peroxisome retrotranslocation channel is comprised of peroxisome biogenesis factor proteins 2, 10 and 12. (UniProt);

NCI Metathesaurus CUI : CL788715;

Details

Origin ID

C204445;

UMLS CUI

C4546647;

OMIM relation
- Peroxisome biogenesis factor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- PEX2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- PEX2 Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Membrane of the Peroxisome [NCIt concept]
gene_product_has_biochemical_function
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Peroxisome Biogenesis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Fatty Acid Metabolism [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Monoubiquitination [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transport Process [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
- Unfolded Protein Response [NCIt concept]

Keyword's position in hierarchy(ies) :

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