E3 Ubiquitin-Protein Ligase CBL-B

Preferred Label : E3 Ubiquitin-Protein Ligase CBL-B;

NCIt synonyms : CBLB; SH3-Binding Protein CBL-B; Signal Transduction Protein CBL-B; EC 6.3.2.-, Formerly; Casitas B-Lineage Lymphoma Proto-Oncogene B; Signal Transduction Protein-CBLB; RING Finger Protein 56; Signal Transduction Protein CBLB; EC 2.3.2.27;

NCIt definition : E3 ubiquitin-protein ligase CBL-B (982 aa, 109 kDa) is encoded by the human CBLB gene. This protein plays a role in the ubiquitination of proteins.;

Details

Origin ID

C21590;

UMLS CUI

C1452695;

OMIM relation
- Cas-br-M murine ecotropic retroviral transforming sequence b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CBLB protein, human [MeSH concept]
- CBLB protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CBLB Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Transferase Gene [NCIt concept]
- Ubiquitin-Transferase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Kidney [NCIt concept]
- Lung [NCIt concept]
- Spleen [NCIt concept]
- Testis [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Ligand Binding Protein [NCIt concept]
- Ubiquitination Regulation Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ring Finger Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- UBA Domain [NCIt concept]
gene_product_is_element_in_pathway
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- CD40/CD40L Signaling Pathway [NCIt concept]
- Calcineurin-Regulated NFAT-Dependent Transcription Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Internalization Pathway for Epidermal Growth Factor Receptor [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- Ubiquitin-mediated Proteolysis Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ubiquitin Protein Ligase [NCIt concept]
gene_product_malfunction_associated_with_disease
- Autoimmune Disease [NCIt concept]
- Type 1 Diabetes Mellitus [NCIt concept]
gene_product_plays_role_in_biological_process
- Signal Transduction [NCIt concept]
- Ubiquitinated Protein Degradation [NCIt concept]
- Ubiquitination [NCIt concept]
is_target
- CBL-B Inhibitor HST-1011 [NCIt concept]
- CBL-B Inhibitor NX-1607 [NCIt concept]

Keyword's position in hierarchy(ies) :

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