Bacterial Invasion of Epithelial Cell Pathway

Preferred Label : Bacterial Invasion of Epithelial Cell Pathway;

NCIt related terms : Bacterial invasion of epithelial cells;

Alternative definition : KEGG: Many pathogenic bacteria can invade phagocytic and non-phagocytic cells, colonize them intracellularly, and then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signaling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.;

KEGG ID : hsa05100;

Details

Origin ID

C91804;

UMLS CUI

C2984569;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Actin Nucleation-Promoting Factor WAS [NCIt concept]
- Actin, Cytoplasmic 1 [NCIt concept]
- Actin, Cytoplasmic 2 [NCIt concept]
- Actin-Binding Protein WASF2 [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- CD2-Associated Protein [NCIt concept]
- Cadherin-1 [NCIt concept]
- Catenin Alpha-1 [NCIt concept]
- Catenin Alpha-2 [NCIt concept]
- Catenin Alpha-3 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Caveolin-1 [NCIt concept]
- Caveolin-2 [NCIt concept]
- Caveolin-3 [NCIt concept]
- Clathrin Heavy Chain 1 [NCIt concept]
- Clathrin Heavy Chain 2 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Dynamin-1 [NCIt concept]
- Dynamin-2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- Engulfment and Cell Motility Protein 1 [NCIt concept]
- Fibronectin [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- GRB2-Associated-Binding Protein 1 [NCIt concept]
- Hepatocyte Growth Factor Receptor [NCIt concept]
- Integrin Alpha-5 [NCIt concept]
- Integrin Beta-1 [NCIt concept]
- Integrin-Linked Protein Kinase [NCIt concept]
- Mitotic Spindle Assembly Checkpoint Protein MAD2B [NCIt concept]
- Neural Wiskott-Aldrich Syndrome Protein [NCIt concept]
- Paxillin [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- SHC-Transforming Protein 3 [NCIt concept]
- SRC Substrate Cortactin [NCIt concept]
- Septin-8 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Vinculin [NCIt concept]
pathway_has_gene_element
- ACTB wt Allele [NCIt concept]
- ACTG1 wt Allele [NCIt concept]
- BCAR1 wt Allele [NCIt concept]
- CAV1 wt Allele [NCIt concept]
- CAV2 wt Allele [NCIt concept]
- CAV3 wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CD2AP wt Allele [NCIt concept]
- CDH1 wt Allele [NCIt concept]
- CLTC wt Allele [NCIt concept]
- CLTCL1 wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- CTNNA1 wt Allele [NCIt concept]
- CTNNA2 wt Allele [NCIt concept]
- CTNNA3 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- CTTN wt Allele [NCIt concept]
- DNM1 wt Allele [NCIt concept]
- DNM2 wt Allele [NCIt concept]
- ELMO1 wt Allele [NCIt concept]
- FN1 wt Allele [NCIt concept]
- GAB1 wt Allele [NCIt concept]
- ILK wt Allele [NCIt concept]
- ITGA5 wt Allele [NCIt concept]
- ITGB1 wt Allele [NCIt concept]
- MAD2L2 wt Allele [NCIt concept]
- MET wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- SEPTIN8 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SHC3 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- VCL wt Allele [NCIt concept]
- WAS wt Allele [NCIt concept]
- WASF2 wt Allele [NCIt concept]
- WASL wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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