Fibronectin - CISMeF

Preferred Label : Fibronectin;

NCIt synonyms : Large External Transformation-Sensitive Protein; LETS Protein; Cold-Insoluble Globulin; FNZ; FN1; Fibronectin 1; FN; LETS; CIG; Large, External, Transformation-Sensitive Protein; Fibronectin Isoform 1; Isoform 1 Fibronectin;

NCIt definition : Fibronectin (2386 aa, 263 kDa) is encoded by the human FN1 gene. This protein is involved in cell adhesion- and migration-dependent processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis.;

NCIt note : Fibronectin can be cleaved to form Ugl-Y1, Ugl-Y2, Ugl-Y3 and anastellin. (UniProt); Anastellin is a 76 amino acid fragment from carboxy-terminal portion of the first fibronectin type-III domain with potential antiangiogenic activity. Anastellin binds fibronectin and induces fibril formation; the resulting fibronectin polymer, superfibronectin, exhibits enhanced adhesive properties and may also inhibit angiogenesis. (UniProt);

NCI Metathesaurus CUI : CL1379609;

Details

Origin ID

C16581;

UMLS CUI

C1570610;

False automatic mappings
- linear energy transfer [MeSH Descriptor]
OMIM relation
- Fibronectin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- FN1 protein, human [MeSH concept]
- FN1 protein, human [MeSH Supplementary Concept]
Validated automatic mappings to NTBT
- fibronectins [MeSH Descriptor]
- fibronectins [MeSH concept]
- fibronectins [Substance BNPC]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Extracellular Matrix Protein Gene [NCIt concept]
- FN1 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelial Cell [NCIt concept]
- Fibroblast [NCIt concept]
- Hepatocyte [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Extracellular Matrix Protein [NCIt concept]
gene_product_has_chemical_classification
- Cell Adhesion Molecule [NCIt concept]
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- Angiopoietin-1 Receptor Signaling Pathway [NCIt concept]
- Bacterial Invasion of Epithelial Cell Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Motility [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Coagulation Process [NCIt concept]
- Host Defense Mechanism [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Wound Repair [NCIt concept]
is_target
- Anti-EDB Antibody-drug Conjugate PYX-201 [NCIt concept]
- Daromun [NCIt concept]
- Dodekin [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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