ECM-Receptor Interaction Signaling Pathway

Preferred Label : ECM-Receptor Interaction Signaling Pathway;

NCIt related terms : ECM-receptor interaction;

Alternative definition : KEGG: The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.;

KEGG ID : hsa04512;

Details

Origin ID

C91515;

UMLS CUI

C2984324;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein [NCIt concept]
- CD44 Antigen [NCIt concept]
- Cartilage Oligomeric Matrix Protein [NCIt concept]
- Collagen Alpha-1(I) Chain [NCIt concept]
- Collagen Alpha-2(I) Chain [NCIt concept]
- Collagen Alpha-2(IV) Chain [NCIt concept]
- Collagen Alpha-3(IV) Chain [NCIt concept]
- Collagen Alpha-3(VI) Chain [NCIt concept]
- Collagen Alpha-6(IV) Chain [NCIt concept]
- Dentin Sialophosphoprotein [NCIt concept]
- Fibronectin [NCIt concept]
- Hyaluronan Mediated Motility Receptor [NCIt concept]
- Integrin Alpha-1 [NCIt concept]
- Integrin Alpha-10 [NCIt concept]
- Integrin Alpha-2 [NCIt concept]
- Integrin Alpha-3 [NCIt concept]
- Integrin Alpha-4 [NCIt concept]
- Integrin Alpha-5 [NCIt concept]
- Integrin Alpha-6 [NCIt concept]
- Integrin Alpha-9 [NCIt concept]
- Integrin Alpha-IIb [NCIt concept]
- Integrin Beta-1 [NCIt concept]
- Integrin Beta-3 [NCIt concept]
- Integrin Beta-4 [NCIt concept]
- Integrin Beta-5 [NCIt concept]
- Integrin Beta-6 [NCIt concept]
- Integrin Beta-7 [NCIt concept]
- Integrin Beta-8 [NCIt concept]
- Laminin Subunit Alpha-2 [NCIt concept]
- Laminin Subunit Alpha-3 [NCIt concept]
- Laminin Subunit Beta-2 [NCIt concept]
- Laminin Subunit Gamma-2 [NCIt concept]
- Leukocyte Surface Antigen CD47 [NCIt concept]
- Osteopontin [NCIt concept]
- Platelet Glycoprotein 4 [NCIt concept]
- Platelet Glycoprotein IX [NCIt concept]
- Platelet Glycoprotein V [NCIt concept]
- Platelet Membrane Glycoprotein 1b Alpha Chain [NCIt concept]
- Platelet Membrane Glycoprotein 1b Beta Chain [NCIt concept]
- Reelin [NCIt concept]
- Syndecan-1 [NCIt concept]
- Syndecan-4 [NCIt concept]
- Tenascin [NCIt concept]
- Vitronectin [NCIt concept]
- von Willebrand Factor [NCIt concept]
pathway_has_gene_element
- CD36 wt Allele [NCIt concept]
- CD44 wt Allele [NCIt concept]
- CD47 wt Allele [NCIt concept]
- COL1A1 wt Allele [NCIt concept]
- COL1A2 wt Allele [NCIt concept]
- COL4A2 wt Allele [NCIt concept]
- COL4A3 wt Allele [NCIt concept]
- COL4A6 wt Allele [NCIt concept]
- COL6A3 wt Allele [NCIt concept]
- COMP wt Allele [NCIt concept]
- DSPP wt Allele [NCIt concept]
- FN1 wt Allele [NCIt concept]
- GP1BA wt Allele [NCIt concept]
- GP1BB wt Allele [NCIt concept]
- GP5 wt Allele [NCIt concept]
- GP9 wt Allele [NCIt concept]
- HMMR wt Allele [NCIt concept]
- HSPG2 wt Allele [NCIt concept]
- ITGA1 wt Allele [NCIt concept]
- ITGA10 wt Allele [NCIt concept]
- ITGA2 wt Allele [NCIt concept]
- ITGA2B wt Allele [NCIt concept]
- ITGA3 wt Allele [NCIt concept]
- ITGA4 wt Allele [NCIt concept]
- ITGA5 wt Allele [NCIt concept]
- ITGA6 wt Allele [NCIt concept]
- ITGA9 wt Allele [NCIt concept]
- ITGB1 wt Allele [NCIt concept]
- ITGB3 wt Allele [NCIt concept]
- ITGB4 wt Allele [NCIt concept]
- ITGB5 wt Allele [NCIt concept]
- ITGB6 wt Allele [NCIt concept]
- ITGB7 wt Allele [NCIt concept]
- ITGB8 wt Allele [NCIt concept]
- LAMA2 wt Allele [NCIt concept]
- LAMA3 wt Allele [NCIt concept]
- LAMB2 wt Allele [NCIt concept]
- LAMC2 wt Allele [NCIt concept]
- RELN wt Allele [NCIt concept]
- SDC1 wt Allele [NCIt concept]
- SDC4 wt Allele [NCIt concept]
- SPP1 wt Allele [NCIt concept]
- TNC wt Allele [NCIt concept]
- VTN wt Allele [NCIt concept]
- VWF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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