Osteopontin - CISMeF

Preferred Label : Osteopontin;

NCIt synonyms : SPP-1; Uropontin; Nephropontin; Bone Sialoprotein 1; Urinary Stone Protein; Secreted Phosphoprotein 1;

NCIt definition : Osteopontin (314 aa, 35 kDa) is encoded by the human SPP1 gene. This protein is involved in the regulation of both tissue mineralization and cell-cell signaling.;

NCIt note : Osteopontin exists in 4 isoforms, and is secreted by secretory phase ductal epithelium. Implicated in the pathogenesis of several cancers.;

Details

Origin ID

C46082;

UMLS CUI

C1505427;

OMIM relation
- Secreted phosphoprotein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Osteopontin (substance) [SNOMED CT concept]
- SPP1 protein, human [MeSH concept]
- SPP1 protein, human [MeSH Supplementary Concept]
- osteopontin [MeSH Descriptor]
- osteopontin [MeSH concept]
- osteopontin [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Extracellular Matrix Protein Gene [NCIt concept]
- SPP1 Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Bone [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_structural_domain_or_motif
- RGD Motif [NCIt concept]
gene_product_is_element_in_pathway
- Bone Mineralization Regulation Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Environment-to-Cell Communication [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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