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Bone Mineralization Regulation Pathway - CISMeF
Bone Mineralization Regulation PathwayNCIt concept
Preferred Label : Bone Mineralization Regulation Pathway;
NCIt related terms : Regulators of Bone Mineralization;
Alternative definition : BIOCARTA: Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation
and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating
the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific
alkaline phosphatase (TNAP) and plasma cell membrane glycoprotein-1 (PC-1) are involved
in this process. In the bone matrix, PC-1 is the major producer of PPi, which in turn
has an inhibitory effect on hydroxyapatite deposition. TNAP has a positive influence
on mineralization primarily by controlling the size of the inhibitory pool of PPi
through its inorganic pyrophosphatase activity. TNAP also generates Pi by using NTPs
and PPi as substrates, but other more major sources of Pi e.g., intestinal absorption,
are likely to contribute the bulk of the Pi needed for hydroxyapatite deposition.
(This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Automatic exact mappings (from CISMeF team)