LAMA3 wt Allele

Preferred Label : LAMA3 wt Allele;

NCIt synonyms : LOCS; Laminin, Alpha 3 Gene; Laminin Subunit Alpha 3 wt Allele; Laminin 5, Alpha-3 Subunit Gene; LAM3, Alpha-3 Subunit Gene; Laminin, Alpha 3 (Nicein (150kD), Kalinin (165kD), BM600 (150kD), Epilegrin) Gene; E170; BM600; LAMNA; Epiligrin, 170-kD Subunit Gene;

NCIt definition : Human LAMA3 wild-type allele is located in the vicinity of 18q11.2 and is approximately 266 kb in length. This allele, which encodes laminin subunit alpha-3 protein, plays a role in cell-matrix attachment.;

NCIt note : Overexpression of the LAMA3 gene may inhibit PD-1 immunotherapy. (Clinical Cancer Research. 2017; doi:10.1158/1078-0432.CCR-17-0270.);

NCI Metathesaurus CUI : CL524950;

GenBank Accession Number : L34155;

Details

Origin ID

C137976;

UMLS CUI

C4521351;

Automatic exact mappings (from CISMeF team)
- Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous [OMIM Phenotype]
- Kalinin [MeSH Descriptor]
- Laminin, alpha-3 [OMIM gene]
- calcium carbonate [MeSH Descriptor]
- kalinin [MeSH Supplementary Concept]
- laminin subunit alpha 3 [ORDO Gene]
- lateral occipital sulcus [UBERON concept]
OMIM relation
- Laminin, alpha-3 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 18q11.2 [NCIt concept]
gene_is_element_in_pathway
- Agrin Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- Amoebiasis Pathway [NCIt concept]
- ECM-Receptor Interaction Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Small Cell Lung Cancer Pathway [NCIt concept]
- Syndecan-2-Mediated Signaling Pathway [NCIt concept]
- Syndecan-4-Mediated Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Histogenic Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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