Small Cell Lung Cancer Pathway

Preferred Label : Small Cell Lung Cancer Pathway;

NCIt synonyms : SCLC Pathway;

NCIt related terms : Small cell lung cancer;

Alternative definition : KEGG: Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 20% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumor suppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.;

KEGG ID : hsa05222;

Details

Origin ID

C91502;

UMLS CUI

C2984312;

Automatic exact mappings (from CISMeF team)
- Small cell cancer of the lung [OMIM Phenotype]
- Small cell carcinoma of lung (disorder) [SNOMED CT concept]
- Small cell lung cancer [ORDO Disease]
- Small cell lung cancer [MedDRA Preferred Term]
- Small cell lung cancer stage unspecified [MedDRA LLT]
- carcinoma, small cell [MeSH Descriptor]
- lung cancer [MedlinePlus Topic]
- small cell lung carcinoma [MeSH Descriptor]
See also inter- (CISMeF)
- Small cell lung carcinoma [HPO term]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Activated Caspase-9 [NCIt concept]
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
- Bis(5'-Adenosyl)-Triphosphatase [NCIt concept]
- Caspase-9 [NCIt concept]
- Collagen Alpha-2(IV) Chain [NCIt concept]
- Collagen Alpha-3(IV) Chain [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Cyclin-Dependent Kinases Regulatory Subunit 1 [NCIt concept]
- Cyclin-Dependent Kinases Regulatory Subunit 2 [NCIt concept]
- Cytochrome C [NCIt concept]
- Fibronectin [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Integrin Alpha-2 [NCIt concept]
- Integrin Alpha-3 [NCIt concept]
- Integrin Alpha-6 [NCIt concept]
- Integrin Alpha-IIb [NCIt concept]
- Integrin Alpha-V [NCIt concept]
- Integrin Beta-1 [NCIt concept]
- Laminin Subunit Alpha-2 [NCIt concept]
- Laminin Subunit Alpha-3 [NCIt concept]
- Laminin Subunit Beta-2 [NCIt concept]
- Laminin Subunit Gamma-2 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Nitric Oxide Synthase, Inducible [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Max [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Retinoic Acid Receptor Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Gamma [NCIt concept]
- TNF Receptor-Associated Factor 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 3 [NCIt concept]
- TNF Receptor-Associated Factor 4 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor E2F2 [NCIt concept]
- Transcription Factor E2F3 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- APAF1 wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CKS1B wt Allele [NCIt concept]
- CKS2 wt Allele [NCIt concept]
- COL4A2 wt Allele [NCIt concept]
- COL4A3 wt Allele [NCIt concept]
- CYCS wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- E2F2 wt Allele [NCIt concept]
- E2F3 wt Allele [NCIt concept]
- FN1 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- ITGA2 wt Allele [NCIt concept]
- ITGA2B wt Allele [NCIt concept]
- ITGA3 wt Allele [NCIt concept]
- ITGA6 wt Allele [NCIt concept]
- ITGAV wt Allele [NCIt concept]
- ITGB1 wt Allele [NCIt concept]
- LAMA2 wt Allele [NCIt concept]
- LAMA3 wt Allele [NCIt concept]
- LAMB2 wt Allele [NCIt concept]
- LAMC2 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NOS2 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RARB wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- RXRB wt Allele [NCIt concept]
- RXRG wt Allele [NCIt concept]
- TRAF1 wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF3 wt Allele [NCIt concept]
- TRAF4 wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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