Agrin Pathway - CISMeF

Preferred Label : Agrin Pathway;

NCIt related terms : Agrin in Postsynaptic Differentiation;

Alternative definition : BIOCARTA: The heparan sulfate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization. Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_agrPathway;

Details

Origin ID

C38975;

UMLS CUI

C1510836;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- ARF GTPase-Activating Protein GIT2 [NCIt concept]
- Cell Division Control Protein 42 Homolog [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- Laminin Subunit Alpha-3 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Muscarinic Acetylcholine Receptor M1 [NCIt concept]
- Muscle, Skeletal Receptor Tyrosine-Protein Kinase [NCIt concept]
- Neuregulin-1 [NCIt concept]
- Neuregulin-2 [NCIt concept]
- Neuregulin-3 [NCIt concept]
- Paxillin [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- SRC Substrate Cortactin [NCIt concept]
- Segment Polarity Protein Dishevelled Homolog DVL-1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 3 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor Sp1 [NCIt concept]
pathway_has_gene_element
- CDC42 wt Allele [NCIt concept]
- CHRM1 wt Allele [NCIt concept]
- CTTN wt Allele [NCIt concept]
- DVL1 wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- GIT2 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LAMA3 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MUSK wt Allele [NCIt concept]
- NRG1 wt Allele [NCIt concept]
- NRG2 wt Allele [NCIt concept]
- NRG3 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PAK3 wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- SP1 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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