Neuregulin-2 - CISMeF

Preferred Label : Neuregulin-2;

NCIt synonyms : DON1; NTAK; Neural- and Thymus-Derived Activator for ErbB Kinases; DON-1; Divergent of Neuregulin 1; NRG-2; NRG2; Neuregulin-2 Protein; Neural- and Thymus-Derived Activator for the ErbB Kinase; Divergent of Neuregulin-1; Neuregulin 2;

NCIt definition : Neuregulin-2 (293 aa, 32 kDa) is encoded by the human NRG2 gene. This protein is involved in the induction of tyrosine kinase receptor-mediated signal transduction.;

NCIt note : Neuregulin-2 is a direct ligand for ERBB3 and ERBB4.; The active form of the growth factor, neuregulin-2, is produced by two proteolytic cleavage events that remove the 111 N-terminal amino acid propeptide and 446 amino acids from the C-terminus of pro-neuregulin-2, membrane-bound isoform. The precursor is a type I membrane protein and the mature form is a secreted protein. (UniProt);

Details

Origin ID

C18175;

UMLS CUI

C1449094;

OMIM relation
- Neuregulin 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- NRG2 protein, human [MeSH concept]
- NRG2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- NRG2 Gene [NCIt concept]
gene_product_expressed_in_tissue
- Nervous System [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- EGF-Like Domain [NCIt concept]
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
gene_product_is_element_in_pathway
- Agrin Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- Gamma-Secretase Mediated ErbB4 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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