Preferred Label : Gamma-Secretase Mediated ErbB4 Signaling Pathway;
NCIt related terms : g-Secretase mediated ErbB4 Signaling Pathway;
Alternative definition : BIOCARTA: The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor
family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differentiation
factors. HER4 can also bind and be activated by heparin-binding EGF growth factor,
betacellulin, and epiregulin, members of the EGF family which, unlike the NRGs, are
also ligands for the EGF receptor. HER4 mRNA is expressed in several tissues such
as heart, brain, kidney, and skeletal muscle, suggesting that this receptor is involved
in the development and maintenance of a variety of organs and cell types. It is likely
that the control of expression and function of HER4 is important in normal development
as well as in disease. (This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_erbB4pathway;
Origin ID : C39070;
UMLS CUI : C1517432;
Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element
