ERBB Family Signaling Pathway

Preferred Label : ERBB Family Signaling Pathway;

NCIt related terms : ErbB signaling pathway;

Alternative definition : KEGG: The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family-epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.;

KEGG ID : hsa04012;

Details

Origin ID

C91514;

UMLS CUI

C2984323;

Semantic type(s)
- Molecular Function [UMLS semantic type]
UMLS correspondences (same concept)
- ERBB signaling pathway [GO term]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-2 [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- Amphiregulin [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Betacellulin [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Cytoplasmic Protein NCK2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Epiregulin [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 [NCIt concept]
- Focal Adhesion Kinase 1 [NCIt concept]
- GRB2-Associated-Binding Protein 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Heparin-Binding EGF-Like Growth Factor [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Neuregulin-1 [NCIt concept]
- Neuregulin-2 [NCIt concept]
- Neuregulin-3 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Src [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 3 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 4 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 5 [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 6 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Signal Transducer and Activator of Transcription 5A [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Transforming Growth Factor Alpha [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Tyrosine-Protein Kinase ABL2 [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- ABL2 wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- AREG wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- BTC wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- EIF4EBP1 wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- EREG wt Allele [NCIt concept]
- GAB1 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HBEGF wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NCK2 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NRG1 wt Allele [NCIt concept]
- NRG2 wt Allele [NCIt concept]
- NRG3 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PAK3 wt Allele [NCIt concept]
- PAK4 wt Allele [NCIt concept]
- PAK5 wt Allele [NCIt concept]
- PAK6 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PLCG2 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PTK2 wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SRC wt Allele [NCIt concept]
- STAT5A wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- TGFA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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