Dual Specificity Mitogen-Activated Protein Kinase Kinase 4

Preferred Label : Dual Specificity Mitogen-Activated Protein Kinase Kinase 4;

NCIt synonyms : MAPKK 4; c-Jun N-Terminal Kinase Kinase 1; MAP Kinase Kinase 4; SAPK/ERK Kinase 1; JNK-Activating Kinase 1; MEK 4; JNKK; SEK1; MAPK/ERK Kinase 4; EC 2.7.12.2; MAP2K4;

NCIt definition : Dual specificity mitogen-activated protein kinase kinase 4 (399 aa, 44 kDa) is encoded by the human MAP2K4 gene. This protein is involved in the modulation of MAPK signaling pathways.;

Details

Origin ID

C97676;

UMLS CUI

C1434639;

Automatic exact mappings (from CISMeF team)
- JUN kinase kinase activity [GO term]
- MAP kinase kinase 4 [MeSH Descriptor]
- MAP kinase kinase 4 [MeSH concept]
- Mitogen-activated protein kinase kinase 4 [OMIM gene]
OMIM relation
- Mitogen-activated protein kinase kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP2K1 protein, human [MeSH Supplementary Concept]
- MAP2K1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- MAP2K4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Androgen Receptor Regulation Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- CD40/CD40L Signaling Pathway [NCIt concept]
- Cellular Anthrax Toxin Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Ephrin B Reverse Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- IL6-Mediated Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- JNK Signaling in the CD4+ TCR Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Nephrin Signaling Pathway in the Kidney Podocyte [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Regulation of p38-alpha and p38-beta Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Kinase Protein Phosphorylation [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]

Keyword's position in hierarchy(ies) :

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