" /> Transforming Growth Factor Alpha - CISMeF





Preferred Label : Transforming Growth Factor Alpha;

NCIt synonyms : Epidermal Growth Factor Related Transforming Growth Factor; TGF A; TGFA; Transforming Growth Factor, Alpha; TGF-Alpha; Transforming Growth Factor-Alpha; ETGF; TGF Type 1; EGF-Like TGF;

NCIt definition : Transforming growth factor alpha (50 aa, 6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation.;

NCIt note : In esophageal adenocarcinoma patients who received high-dose radiation and chemotherapy, tumors that either persistently expressed or had increased TGFA expression was associated with a worse prognosis. (Int J Radiat Oncol Biol Phys. 1995; 31:567-9.); The active form of the growth factor, transforming growth factor alpha, is produced when proteolytic cleavage removes 39 amino acids from the N-terminus and 71 amino acids from the C-terminus of protransforming growth factor alpha. The precursor is a transmembrane protein and the mature form is a secreted protein. (UniProt);

PubMed : 7852121;

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14/05/2024


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