Non-Small Cell Lung Cancer Pathway

Preferred Label : Non-Small Cell Lung Cancer Pathway;

NCIt synonyms : NSCLC Pathway;

NCIt related terms : Non-small cell lung cancer;

Alternative definition : KEGG: Non-small-cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS and c-erbB-2, and inactivation of tumor suppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Overexpression of c-erbB-2 or EGFR leads to a proliferative advantage. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a gene inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptional activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector. Therefore, loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect.;

KEGG ID : hsa05223;

Details

Origin ID

C91445;

UMLS CUI

C2984258;

Automatic exact mappings (from CISMeF team)
- Lung cancer [OMIM Phenotype]
- Non-small cell lung cancer [MedDRA Preferred Term]
- Non-small cell lung cancer (disorder) [SNOMED CT concept]
- carcinoma, non-small-cell lung [MeSH Descriptor]
- lung cancer [MedlinePlus Topic]
- lung non-small cell carcinoma [DO Concept]
See also inter- (CISMeF)
- Non-small cell lung carcinoma [HPO term]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Activated Caspase-9 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Bis(5'-Adenosyl)-Triphosphatase [NCIt concept]
- Caspase-9 [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Echinoderm Microtubule-Associated Protein-Like 4 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Forkhead Box Protein O3 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Kinesin Heavy Chain Isoform 5A [NCIt concept]
- Kinesin-1 Heavy Chain [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Ras Association Domain-Containing Protein 1 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Retinoic Acid Receptor Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Beta [NCIt concept]
- Retinoic Acid Receptor RXR-Gamma [NCIt concept]
- Serine/Threonine-Protein Kinase 4 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor E2F2 [NCIt concept]
- Transcription Factor E2F3 [NCIt concept]
- Transforming Growth Factor Alpha [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CASP9 wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- E2F2 wt Allele [NCIt concept]
- E2F3 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- EML4 wt Allele [NCIt concept]
- ERBB2 wt Allele [NCIt concept]
- FOXO3 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- KIF5A wt Allele [NCIt concept]
- KIF5B wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAX wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- RARB wt Allele [NCIt concept]
- RASSF1 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- RXRB wt Allele [NCIt concept]
- RXRG wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- STK4 wt Allele [NCIt concept]
- TGFA wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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