NCIt synonyms : MYC Associated Factor X wt Allele; PDMCS; MYC-Associated Factor X Gene; BHLHD4;
NCIt definition : Human MAX wild-type allele is located in the vicinity of 14q23 and is approximately
93 kb in length. This allele, which encodes protein max, plays a role in both the
modulation of transcription by RNA polymerase II and chromatin remodeling.;
NCIt note : The MAX gene product forms a sequence-specific DNA-binding protein complex with myc
protein or mad protein which recognizes the core sequence 5'-CAC[GA]TG-3'. The myc-max
protein complex is a transcriptional activator, whereas the mad-max protein complex
is a repressor. Max protein may repress transcription via the recruitment of a chromatin
remodeling complex containing H3-K9 histone methyltransferase activity (GeneCards).;