" /> MAX wt Allele - CISMeF





Preferred Label : MAX wt Allele;

NCIt synonyms : MYC Associated Factor X wt Allele; PDMCS; MYC-Associated Factor X Gene; BHLHD4;

NCIt definition : Human MAX wild-type allele is located in the vicinity of 14q23 and is approximately 93 kb in length. This allele, which encodes protein max, plays a role in both the modulation of transcription by RNA polymerase II and chromatin remodeling.;

NCIt note : The MAX gene product forms a sequence-specific DNA-binding protein complex with myc protein or mad protein which recognizes the core sequence 5'-CAC[GA]TG-3'. The myc-max protein complex is a transcriptional activator, whereas the mad-max protein complex is a repressor. Max protein may repress transcription via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase activity (GeneCards).;

GenBank Accession Number : NM_197957;

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27/05/2025


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