MAPK Signaling Pathway

Preferred Label : MAPK Signaling Pathway;

Alternative definition : KEGG: The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.;

KEGG ID : hsa04010;

Details

Origin ID

C38834;

UMLS CUI

C1518102;

Automatic exact mappings (from CISMeF team)
- map kinase signaling system [MeSH Descriptor]
Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 85 kDa Calcium-Independent Phospholipase A2 [NCIt concept]
- Adapter Molecule crk [NCIt concept]
- BDNF/NT-3 Growth Factors Receptor [NCIt concept]
- Beta-Arrestin-1 [NCIt concept]
- Beta-Arrestin-2 [NCIt concept]
- Beta-Nerve Growth Factor [NCIt concept]
- Brain-Derived Neurotrophic Factor [NCIt concept]
- Calcineurin Subunit B Type 1 [NCIt concept]
- Calcineurin Subunit B Type 2 [NCIt concept]
- Caspase-3 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Cytosolic Phospholipase A2 [NCIt concept]
- Cytosolic Phospholipase A2 Beta [NCIt concept]
- DNA Damage-Inducible Transcript 3 Protein [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- Dual Specificity Protein Phosphatase 1 [NCIt concept]
- Dual Specificity Protein Phosphatase 10 [NCIt concept]
- Dual Specificity Protein Phosphatase 22 [NCIt concept]
- Dual Specificity Protein Phosphatase 3 [NCIt concept]
- Dual Specificity Protein Phosphatase 4 [NCIt concept]
- Dual Specificity Protein Phosphatase 5 [NCIt concept]
- Dual Specificity Protein Phosphatase 6 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- ETS Domain-Containing Protein Elk-4 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Fibroblast Growth Factor 1 [NCIt concept]
- Fibroblast Growth Factor 10 [NCIt concept]
- Fibroblast Growth Factor 13 [NCIt concept]
- Fibroblast Growth Factor 18 [NCIt concept]
- Fibroblast Growth Factor 19 [NCIt concept]
- Fibroblast Growth Factor 2 [NCIt concept]
- Fibroblast Growth Factor 20 [NCIt concept]
- Fibroblast Growth Factor 21 [NCIt concept]
- Fibroblast Growth Factor 22 [NCIt concept]
- Fibroblast Growth Factor 23 [NCIt concept]
- Fibroblast Growth Factor 3 [NCIt concept]
- Fibroblast Growth Factor 4 [NCIt concept]
- Fibroblast Growth Factor 5 [NCIt concept]
- Fibroblast Growth Factor 6 [NCIt concept]
- Fibroblast Growth Factor 7 [NCIt concept]
- Fibroblast Growth Factor 8 [NCIt concept]
- Fibroblast Growth Factor 9 [NCIt concept]
- Fibroblast Growth Factor Receptor 1 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 [NCIt concept]
- Fibroblast Growth Factor Receptor 2 Isoform IIIb [NCIt concept]
- Fibroblast Growth Factor Receptor 3 [NCIt concept]
- Fibroblast Growth Factor Receptor 4 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha [NCIt concept]
- Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(I)/G(S)/G(O) Subunit Gamma-12 [NCIt concept]
- Guanine Nucleotide-Binding Protein Subunit Alpha-12 [NCIt concept]
- Heat Shock 70 kDa Protein 1A/1B [NCIt concept]
- Heat Shock Protein Beta-1 [NCIt concept]
- High Affinity Nerve Growth Factor Receptor [NCIt concept]
- Histone-Lysine N-Methyltransferase MECOM [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interleukin-1 Alpha [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-1 Receptor Accessory Protein [NCIt concept]
- Interleukin-1 Receptor Type 1 [NCIt concept]
- Interleukin-1 Receptor Type 2 [NCIt concept]
- MAP Kinase-Activated Protein Kinase 2 [NCIt concept]
- MAP Kinase-Activated Protein Kinase 5 [NCIt concept]
- MECOM Protein Isoform Evi-1a [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 4 [NCIt concept]
- Mitogen-Activated Protein Kinase 6 [NCIt concept]
- Mitogen-Activated Protein Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 4 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 5 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 [NCIt concept]
- Monocyte Differentiation Antigen CD14 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Neurofibromin [NCIt concept]
- Neurotrophin-3 [NCIt concept]
- Nuclear Factor NF-kappa-B p100 Subunit [NCIt concept]
- Nuclear Factor NF-kappa-B p105 Subunit [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 2 [NCIt concept]
- Nuclear Factor of Activated T-Cells, Cytoplasmic 4 [NCIt concept]
- Nuclear Receptor Subfamily 4 Group A Member 1 [NCIt concept]
- Platelet-Derived Growth Factor Subunit A [NCIt concept]
- Platelet-Derived Growth Factor Subunit B [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Max [NCIt concept]
- Proto-Oncogene Serine/Threonine-Protein Kinase mos [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- RAS Guanyl-Releasing Protein 1 [NCIt concept]
- RAS-Related Protein Rap-1A [NCIt concept]
- Rap Guanine Nucleotide Exchange Factor 2 [NCIt concept]
- Ras GTPase-Activating Protein 1 [NCIt concept]
- Ras GTPase-Activating Protein 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 3 [NCIt concept]
- Ras-Related Protein M-Ras [NCIt concept]
- Ras-Related Protein R-Ras [NCIt concept]
- Ras-Related Protein R-Ras2 [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 1 [NCIt concept]
- Ras-Specific Guanine Nucleotide-Releasing Factor 2 [NCIt concept]
- Receptor-Type Tyrosine-Protein Phosphatase R [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-3 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-4 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-5 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-6 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase 3 [NCIt concept]
- Serine/Threonine-Protein Kinase 4 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase NLK [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Serine/Threonine-Protein Kinase TAO1 [NCIt concept]
- Serine/Threonine-Protein Kinase TAO3 [NCIt concept]
- Serum Response Factor [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Stathmin [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- TGF-Beta-Activated Kinase 1 and MAP3K7-Binding Protein 1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor Jun-D [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 7 [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1C [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1D [NCIt concept]
- Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1S [NCIt concept]
- Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1A [NCIt concept]
- Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ACVR1B wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARRB1 wt Allele [NCIt concept]
- ARRB2 wt Allele [NCIt concept]
- BDNF wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CACNA1A wt Allele [NCIt concept]
- CACNA1C wt Allele [NCIt concept]
- CACNA1D wt Allele [NCIt concept]
- CACNA1G wt Allele [NCIt concept]
- CACNA1S wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CD14 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- DDIT3 wt Allele [NCIt concept]
- DUSP1 wt Allele [NCIt concept]
- DUSP10 wt Allele [NCIt concept]
- DUSP22 wt Allele [NCIt concept]
- DUSP3 wt Allele [NCIt concept]
- DUSP4 wt Allele [NCIt concept]
- DUSP5 wt Allele [NCIt concept]
- DUSP6 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- ELK4 wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- FGF1 wt Allele [NCIt concept]
- FGF10 wt Allele [NCIt concept]
- FGF13 wt Allele [NCIt concept]
- FGF18 wt Allele [NCIt concept]
- FGF19 wt Allele [NCIt concept]
- FGF2 wt Allele [NCIt concept]
- FGF20 wt Allele [NCIt concept]
- FGF21 wt Allele [NCIt concept]
- FGF22 wt Allele [NCIt concept]
- FGF23 wt Allele [NCIt concept]
- FGF3 wt Allele [NCIt concept]
- FGF4 wt Allele [NCIt concept]
- FGF5 wt Allele [NCIt concept]
- FGF6 wt Allele [NCIt concept]
- FGF7 wt Allele [NCIt concept]
- FGF8 wt Allele [NCIt concept]
- FGF9 wt Allele [NCIt concept]
- FGFR1 wt Allele [NCIt concept]
- FGFR2 wt Allele [NCIt concept]
- FGFR3 wt Allele [NCIt concept]
- FGFR4 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GADD45A wt Allele [NCIt concept]
- GADD45B wt Allele [NCIt concept]
- GNA12 wt Allele [NCIt concept]
- GNG12 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- HSPA1A wt Allele [NCIt concept]
- HSPA1B wt Allele [NCIt concept]
- HSPB1 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IL1A wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL1R1 wt Allele [NCIt concept]
- IL1R2 wt Allele [NCIt concept]
- IL1RAP wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- JUND wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K13 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP3K3 wt Allele [NCIt concept]
- MAP3K4 wt Allele [NCIt concept]
- MAP3K5 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAP4K1 wt Allele [NCIt concept]
- MAP4K3 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK4 wt Allele [NCIt concept]
- MAPK6 wt Allele [NCIt concept]
- MAPK7 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MAPKAPK2 wt Allele [NCIt concept]
- MAPKAPK5 wt Allele [NCIt concept]
- MAX wt Allele [NCIt concept]
- MECOM wt Allele [NCIt concept]
- MKNK2 wt Allele [NCIt concept]
- MOS wt Allele [NCIt concept]
- MRAS wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NF1 wt Allele [NCIt concept]
- NFATC2 wt Allele [NCIt concept]
- NFATC4 wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKB2 wt Allele [NCIt concept]
- NGF wt Allele [NCIt concept]
- NLK wt Allele [NCIt concept]
- NR4A1 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- NTF3 wt Allele [NCIt concept]
- NTRK1 wt Allele [NCIt concept]
- NTRK2 wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- PDGFA wt Allele [NCIt concept]
- PDGFB wt Allele [NCIt concept]
- PLA2G4A wt Allele [NCIt concept]
- PLA2G4B wt Allele [NCIt concept]
- PLA2G6 wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PPP3CB wt Allele [NCIt concept]
- PPP3CC wt Allele [NCIt concept]
- PPP3R1 wt Allele [NCIt concept]
- PPP3R2 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- PTPN7 wt Allele [NCIt concept]
- PTPRR wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAC3 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RAP1A wt Allele [NCIt concept]
- RAPGEF2 wt Allele [NCIt concept]
- RASA1 wt Allele [NCIt concept]
- RASA2 wt Allele [NCIt concept]
- RASGRF1 wt Allele [NCIt concept]
- RASGRF2 wt Allele [NCIt concept]
- RASGRP1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RPS6KA1 wt Allele [NCIt concept]
- RPS6KA2 wt Allele [NCIt concept]
- RPS6KA3 wt Allele [NCIt concept]
- RPS6KA4 wt Allele [NCIt concept]
- RPS6KA5 wt Allele [NCIt concept]
- RPS6KA6 wt Allele [NCIt concept]
- RRAS wt Allele [NCIt concept]
- RRAS2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SRF wt Allele [NCIt concept]
- STK3 wt Allele [NCIt concept]
- STK4 wt Allele [NCIt concept]
- STMN1 wt Allele [NCIt concept]
- TAB1 wt Allele [NCIt concept]
- TAOK1 wt Allele [NCIt concept]
- TAOK3 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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