Nuclear Receptor Subfamily 4 Group A Member 1

Preferred Label : Nuclear Receptor Subfamily 4 Group A Member 1;

NCIt synonyms : Early Response Protein NAK1; Growth Factor-Inducible Nuclear Protein N10; Early Response Protein-NAK1; TR3 Orphan Receptor; Growth Factor Response Protein 1; Orphan Nuclear Receptor HMR; Nuclear Hormone Receptor TR3; NR4A1; Steroid Receptor TR3; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Hormone Receptor NUR/77; Nur77; Testicular Receptor 3; ST-59; Orphan Nuclear Receptor TR3;

NCIt definition : Nuclear receptor subfamily 4 group A member 1 (598 aa, 64 kDa) is encoded by the human NR4A1 gene. This protein is involved in the regulation of gene expression.;

NCIt note : Nuclear Receptor Subfamily 4 Group A Member 1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Its expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. (from LocusLink);

Details

Origin ID

C30088;

UMLS CUI

C1700524;

Currated CISMeF NLP mapping
- nuclear receptor subfamily 4, group A, member 1 [MeSH Descriptor]
- nuclear receptor subfamily 4, group A, member 1 [MeSH concept]
OMIM relation
- Nuclear receptor subfamily 4, group a, member 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- NR4A1 protein, human [MeSH concept]
- NR4A1 protein, human [MeSH Supplementary Concept]
- nuclear receptor subfamily 4, group A, member 1 [MeSH concept]
- nuclear receptor subfamily 4, group A, member 1 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- NR4A1 Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcineurin-Dependent NFAT Signaling Pathway in Lymphocytes [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- RXR and RAR Heterodimerization with Other Nuclear Receptor Signaling Pathway [NCIt concept]
- T-Cell Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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