Preferred Label : Nuclear Receptor Gene;
NCIt definition : Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor
(NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors
(unknown ligands). Transducing hormone signals into gene transcription, NRs regulate
development, pattern formation, cell proliferation, cell differentiation, and homeostasis
in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved
central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive
target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc
finger interactions contribute to DNA binding specificity, homodimerization, and interaction
with other proteins. Ligand-bound NR conformation allows coactivator interaction with
the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins,
and hormone. (NCI);
Origin ID : C20709;
UMLS CUI : C1335077;
Semantic type(s)
- gene_encodes_gene_product
- gene_found_in_organism
- gene_plays_role_in_process
