Thyroid Hormone Receptor Alpha

Preferred Label : Thyroid Hormone Receptor Alpha;

NCIt synonyms : THRA; C-ERBA-ALPHA-1; ERBA-Alpha Protein; ERBA-Related Protein 7; THRA Protein; c-erbA-1; Nuclear Receptor Subfamily 1 Group A Member 1; V-erbA-Related Protein 7; c-erbA-alpha; EAR-7; Thyroid Hormone Receptor Alpha-1; NR1A1;

NCIt definition : Thyroid hormone receptor alpha (490 aa, 55 kDa) is encoded by the human THRA gene. This protein is involved in thyroid hormone-mediated transcriptional regulation.;

NCIt note : 2 isoforms produced by alternate splicing;

Details

Origin ID

C19920;

UMLS CUI

C5441862;

Currated CISMeF NLP mapping
- thyroid hormone receptor alpha-1 [MeSH concept]
OMIM relation
- Thyroid hormone receptor, alpha-1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- thyroid hormone receptor alpha-1 [MeSH concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Nuclear Receptor Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- THRA Gene [NCIt concept]
- Thyroid Hormone Receptor Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Central Nervous System [NCIt concept]
- Cytoplasm [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Hormone Receptor [NCIt concept]
- Receptor [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
gene_product_has_chemical_classification
- Nuclear Hormone Receptor Superfamily [NCIt concept]
gene_product_has_structural_domain_or_motif
- Hormone Receptor DNA-Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- DNA Binding [NCIt concept]
- Homeostatic Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Maturation [NCIt concept]
- Pattern Formation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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