Map Kinase Inactivation of SMRT Corepressor Pathway

Preferred Label : Map Kinase Inactivation of SMRT Corepressor Pathway;

NCIt related terms : Map Kinase Inactivation of SMRT Corepressor;

Alternative definition : BIOCARTA: Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EGF receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_egfr_smrtePathway;

Details

Origin ID

C39059;

UMLS CUI

C1512988;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Nuclear Receptor Corepressor 2 [NCIt concept]
- Nuclear Receptor Subfamily 1 Group D Member 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Retinoic Acid Receptor Alpha [NCIt concept]
- Retinoic Acid Receptor RXR-Alpha [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Thyroid Hormone Receptor Alpha [NCIt concept]
- Zinc Finger and BTB Domain-Containing Protein 16 [NCIt concept]
pathway_has_gene_element
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- NCOR2 wt Allele [NCIt concept]
- NR1D1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RARA wt Allele [NCIt concept]
- RXRA wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- THRA wt Allele [NCIt concept]
- ZBTB16 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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