Dual Specificity Mitogen-Activated Protein Kinase Kinase 2

Preferred Label : Dual Specificity Mitogen-Activated Protein Kinase Kinase 2;

NCIt synonyms : MAPKK 2; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinase 2; MAPK/ERK Kinase 2; EC 2.7.12.2; MAP2K2; ERK Activator Kinase 2; MEK 2;

NCIt definition : Dual specificity mitogen-activated protein kinase kinase 2 (400 aa, 44 kDa) is encoded by the human MAP2K2 gene. This protein plays a role in protein phosphorylation.;

Details

Origin ID

C106633;

UMLS CUI

C1434641;

Automatic exact mappings (from CISMeF team)
- MAP kinase kinase 2 [MeSH concept]
- MAP kinase kinase 2 [MeSH Descriptor]
- Mitogen-activated protein kinase kinase 2 [OMIM gene]
- mitogen-activated protein kinase kinase 2 [ORDO Gene]
- mitogen-activated protein kinase kinase 2 [HGNC gene]
OMIM relation
- Mitogen-activated protein kinase kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP2K2 protein, human [MeSH Supplementary Concept]
- MAP2K2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- MAP2K2 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- MAP2K2 NP_109587.1:p.P128L [NCIt concept]
- MAP2K2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- Anthrax Toxin Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Calpain-2 Cell Motility Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- Cellular Anthrax Toxin Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAP Kinase Activation Pathway [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- Melanocyte Development Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- Phospholipid Signaling Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Splicing Regulation Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Intracellular Transport [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Binimetinib [NCIt concept]
- MEK 1/2 Inhibitor AS703988/MSC2015103B [NCIt concept]
- MEK 1/2 Inhibitor FCN-159 [NCIt concept]
- MEK Inhibitor CI-1040 [NCIt concept]
- MEK Inhibitor IMM-1-104 [NCIt concept]
- MEK Inhibitor REC-4881 [NCIt concept]
- MEK1/2 Inhibitor ABM-168 [NCIt concept]
- Mirdametinib [NCIt concept]
- Pimasertib [NCIt concept]
- Pimasertib Hydrochloride [NCIt concept]
- Selumetinib [NCIt concept]
- Selumetinib Sulfate [NCIt concept]
- Trametinib [NCIt concept]
- Trametinib Dimethyl Sulfoxide [NCIt concept]

Keyword's position in hierarchy(ies) :

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