Preferred Label : Pimasertib Hydrochloride;
NCIt definition : The hydrochloride salt form of pimasertib, an orally bioavailable small-molecule inhibitor
of mitogen activated protein kinase kinases 1 (MEK1) and 2 (MEK2), with potential
antineoplastic activity. Upon oral administration, pimasertib selectively binds to
and inhibits the activity of MEK1 and 2, thereby preventing the activation of MEK1/2-dependent
effector proteins and transcription factors. This results in the inhibition of growth
factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are
dual-specificity threonine/tyrosine kinases that play key roles in the activation
of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell
types.;
UNII : 6GS1ULF5HV;
InChIKey : HIEXZUXKTABHCP-PPHPATTJSA-N;
CAS number : 1236361-78-6;
NCI Metathesaurus CUI : CL972181;
Origin ID : C166935;
UMLS CUI : C5239588;
Semantic type(s)
- concept_is_in_subset
- has_target
