Dual Specificity Mitogen-Activated Protein Kinase Kinase 1

Preferred Label : Dual Specificity Mitogen-Activated Protein Kinase Kinase 1;

NCIt synonyms : MAP2K1; MAPK/ERK Kinase 1; Mitogen-Activated Protein Kinase Kinase-1; MAP Kinase Kinase 1; ERK Activator Kinase 1; MEK-1; MEK 1; EC 2.7.12.2; MAP2K1 Protein; MAPKK 1; MKK1;

NCIt definition : Dual specificity mitogen-activated protein kinase kinase 1 (393 aa, 43 kDa) is encoded by the human MAP2K1 gene. This protein plays a role in protein phosphorylation and the MAP kinase signal transduction pathway.;

NCIt note : A component of the RAS intracellular signaling pathway, MAP2K1 is a critical activating protein kinase of MAP kinase. p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway. (Yu et al. Curr Biol 1998. 8:56-64 and OMIMI);

Details

Origin ID

C17808;

UMLS CUI

C1434639;

Automatic exact mappings (from CISMeF team)
- MAP kinase kinase activity [GO term]
- MAP kinase kinase kinase 1 [MeSH Descriptor]
- MAP kinase kinase kinase 1 [MeSH concept]
- Mitogen-activated protein kinase kinase 1 [OMIM gene]
- mitogen-activated protein kinase kinase 1 [ORDO Gene]
Currated CISMeF NLP mapping
- MAP kinase kinase 1 [MeSH Descriptor]
- MAP kinase kinase 1 [MeSH concept]
OMIM relation
- Mitogen-activated protein kinase kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP2K1 protein, human [MeSH concept]
- MAP2K1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- MAP2K1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Angiotensin II Signaling Pathway [NCIt concept]
- Anthrax Toxin Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- CCR3 Signaling Pathway [NCIt concept]
- CXCR4 Signaling Pathway [NCIt concept]
- Cadmium Induction Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Chemokine Signaling Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- EGF Signaling Pathway [NCIt concept]
- EPO Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Erk1/Erk2 MAPK Signaling Pathway [NCIt concept]
- Extracellular Matrix Binding Pathway [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Formyl Peptide Receptor 1 Signaling Pathway [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- GPCR Signaling Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Gonadotropin-Releasing Hormone Signaling Pathway [NCIt concept]
- Growth Hormone Signaling Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- IGF-1 Signaling Pathway [NCIt concept]
- IGF1R Antiapoptosis Pathway [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL3 Signaling Pathway [NCIt concept]
- IL6 Signaling Pathway [NCIt concept]
- Inhibition of Cellular Proliferation by Gleevec Pathway [NCIt concept]
- Insulin Signaling Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Integrin Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- MAP Kinase Activation Pathway [NCIt concept]
- MAP Kinase Downregulation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Nerve Growth Factor Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Oocyte Maturation Pathway [NCIt concept]
- PDGF Signaling Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- Prion Disease Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Pyk2 and Map Kinase Pathway [NCIt concept]
- Ras Signaling Pathway [NCIt concept]
- Ras-Independent Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- SRF Activation Pathway [NCIt concept]
- Sprouty Regulation of Tyrosine Kinase Signaling Pathway [NCIt concept]
- T Cell Receptor Signaling Pathway BioCarta [NCIt concept]
- T Cell Receptor Signaling Pathway KEGG [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
- VEGF Signaling Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Binimetinib [NCIt concept]
- Cobimetinib [NCIt concept]
- Luvometinib [NCIt concept]
- MEK 1/2 Inhibitor AS703988/MSC2015103B [NCIt concept]
- MEK Inhibitor AZD8330 [NCIt concept]
- MEK Inhibitor CI-1040 [NCIt concept]
- MEK Inhibitor GDC-0623 [NCIt concept]
- MEK Inhibitor IMM-1-104 [NCIt concept]
- MEK Inhibitor IMM-6-415 [NCIt concept]
- MEK Inhibitor REC-4881 [NCIt concept]
- MEK Inhibitor RO4987655 [NCIt concept]
- MEK-1/MEKK-1 Inhibitor E6201 [NCIt concept]
- MEK/RAF Molecular Glue IK-595 [NCIt concept]
- MEK1/2 Inhibitor ABM-168 [NCIt concept]
- MEK1/2 Inhibitor PAS-004 [NCIt concept]
- Mirdametinib [NCIt concept]
- Pan-RAF/MEK Molecular Glue NST-628 [NCIt concept]
- Pimasertib [NCIt concept]
- Pimasertib Hydrochloride [NCIt concept]
- Refametinib [NCIt concept]
- Selumetinib [NCIt concept]
- Selumetinib Sulfate [NCIt concept]
- Trametinib [NCIt concept]
- Trametinib Dimethyl Sulfoxide [NCIt concept]

Keyword's position in hierarchy(ies) :

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