Cardiac Hypertrophy Pathway

Preferred Label : Cardiac Hypertrophy Pathway;

NCIt related terms : Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy;

Alternative definition : BIOCARTA: One of responses to increased blood pressure is cardiac hypertrophy through increased size of ventricular myocardial cells leading to increased thickness of the ventricular walls. Cardiac hypertrophy allows the heart to handle the increased stress caused by elevated blood pressure but is also a risk factor associated with heart disease. Cardiac hypertrophy results from cross-talk between G-protein coupled receptor signaling and the EGF receptor pathway. Several GPCR ligands are known to stimulate cardiac hypertrophy, including factors that regulate blood pressure such as angiotensin II and endothelin-1. These factors stimulate phospholipase C through Gq activation, and the production of 1P3 and diacylglycerol second messengers. PKC-delta is activated by DAG and interacts with the metalloproteinase ADAM12. ADAM12 cleaves the membrane-bound HB-EGF to release soluble EGF ligand that activates EGF receptor in myocardial cells. EGF receptor activation downstream through small G proteins and the MAP kinase pathway ultimately leads to cardiac hypertrophy. Signals by GPCR ligands such as angiotensin II result in transcriptional translation of immediate early genes like fos and other genes involved in long-term remodeling of heart tissue and the physiological response to stress in the heart such as the atrial natriuretic factor. Factors such as the AKT kinase, reactive oxygen species (ROS) and NE-kB also are involved in signaling that leads to hypertrophy, although their role is not yet clear. Blocking this pathway at various steps may prevent heart disease through the prevention of cardiac hypertrophy, but may also have other consequences. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_cardiacegfPathway;

Details

Origin ID

C39011;

UMLS CUI

C1516292;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Gamma-1 [NCIt concept]
- Angiotensin-1 [NCIt concept]
- Angiotensinogen [NCIt concept]
- Disintegrin and Metalloproteinase Domain-Containing Protein 12 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Endothelin-1 [NCIt concept]
- Epidermal Growth Factor [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- GTPase HRas [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
- Type-2 Angiotensin II Receptor [NCIt concept]
pathway_has_gene_element
- ADAM12 wt Allele [NCIt concept]
- AGT wt Allele [NCIt concept]
- AGTR2 wt Allele [NCIt concept]
- EDN1 wt Allele [NCIt concept]
- EGF wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- MYH6 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PLCG1 wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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