Angiotensinogen

Preferred Label : Angiotensinogen;

NCIt synonyms : AGT; Pre-Angiotensinogen; Serpin A8;

NCIt definition : Angiotensinogen (485 aa, 53 kDa) is encoded by the human AGT gene. This protein plays a role in the regulation of blood pressure, body fluid and electrolyte homeostasis.;

NCIt note : Angiotensinogen can be cleaved into the following peptides: Angiotensin-1 (Angiotensin 1-10; Angiotensin I; Ang I), Angiotensin-2 (Angiotensin 1-8; Angiotensin II; Ang II); Angiotensin-3 (Angiotensin 2-8; Angiotensin III; Ang III; Des-Asp[1]-angiotensin II), Angiotensin-4 (Angiotensin 3-8; Angiotensin IV; Ang IV), Angiotensin 1-9, Angiotensin 1-7, Angiotensin 1-5, and Angiotensin 1-4. (UniProt);

Details

Origin ID

C136723;

UMLS CUI

C2713666;

Automatic exact mappings (from CISMeF team)
- Alanine-glyoxylate aminotransferase [OMIM gene]
- alanine--glyoxylate aminotransferase [ORDO Gene]
- amnesia, transient global [MeSH Descriptor]
- angiotensinogen [ORDO Gene]
- angiotensinogen [HGNC gene]
- trans fatty acids [MeSH Descriptor]
Currated CISMeF NLP mapping
- Angiotensinogen [OMIM Phenotype]
- Angiotensinogen [LOINC component]
- Angiotensinogen (substance) [SNOMED CT concept]
- angiotensinogen [MeSH concept]
- angiotensinogen [SNOMED Notion]
- angiotensinogen [MeSH Descriptor]
OMIM relation
- Angiotensinogen [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AGT protein, human [MeSH Supplementary Concept]
- AGT protein, human [MeSH concept]
gene_encodes_gene_product
- AGT Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Serine Proteinase Inhibitor Protein [NCIt concept]
gene_product_has_chemical_classification
- Serpin [NCIt concept]
gene_product_is_element_in_pathway
- Angiotensin II Signaling Pathway [NCIt concept]
- Angiotensin-converting Enzyme 2 Pathway [NCIt concept]
- Bioactive Peptide Signaling Pathway [NCIt concept]
- Cardiac Hypertrophy Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- Renin-Angiotensin Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Metabolism, Minerals/Electrolytes [NCIt concept]
has_gene_product_element
- Angiotensin-1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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