" /> MYC wt Allele - CISMeF





Preferred Label : MYC wt Allele;

NCIt synonyms : v-MYC Myelocytomatosis Viral Oncogene Homolog (Avian) Gene; C-MYC; bHLHe39; MRTL; v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog wt Allele; MYCC;

NCIt definition : Human MYC wild-type allele is located in the vicinity of 8q24.21 and is approximately 5 kb in length. This allele, which encodes myc proto-oncogene protein, plays a role in the regulation of transcription by RNA polymerase II. Burkitt's lymphoma is associated with at least three translocations, t(2;8)(p12;q24), t(8;14)(q24;q32) and t(8;22)(q24;q11) which fuse the gene to the promoter site for either the immunoglobin heavy or light chain genes. In a variety of other tumors the gene is expressed aberrantly.;

NCIt note : The MYC gene product can bind DNA in a non-specific manner and can specifically recognize the core sequence 5'-CAC[GA]TG-3' (GeneCards). The MYC gene is expressed at elevated levels in many types of tumors, including breast, cervical and colon, gastric and ovarian cancers, as well as in squamous cell carcinomas of the head and neck, myeloma and non-Hodgkin's lymphoma. (Atlas of Genetics and Cytogenetics in Hematology and Oncology).;

GenBank Accession Number : NM_002467;

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11/05/2024


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