T-Cell Antiapoptosis Pathway

Preferred Label : T-Cell Antiapoptosis Pathway;

NCIt related terms : Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells;

Alternative definition : BIOCARTA: Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_vipPathway;

Details

Origin ID

C39266;

UMLS CUI

C1515123;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- E3 SUMO-Protein Ligase EGR2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(q) Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform [NCIt concept]
- Vasoactive Intestinal Peptide [NCIt concept]
- Vasoactive Intestinal Polypeptide Receptor 2 [NCIt concept]
- cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit [NCIt concept]
- cAMP-Dependent Protein Kinase Type II-Alpha Regulatory Subunit [NCIt concept]
pathway_has_gene_element
- CHUK wt Allele [NCIt concept]
- EGR2 wt Allele [NCIt concept]
- GNAQ wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PPP3CA wt Allele [NCIt concept]
- PRKAR1A wt Allele [NCIt concept]
- PRKAR2A wt Allele [NCIt concept]
- VIP wt Allele [NCIt concept]
- VIPR2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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