NCIt synonyms : Protein Kinase, cAMP-Dependent, Regulatory, Type I, Alpha (Tissue Specific Extinguisher
1) wt Allele; ADOHR; TSE1; CNC1; Protein Kinase A Type 1a Regulatory Subunit Gene; DKFZp779L0468; CNC; MGC17251; PPNAD1; CAR; PRKAR1; PKR1;
NCIt definition : Human PRKAR1A wild-type allele is located within 17q23-q24 and is approximately 21
kb in length. This allele, which encodes cAMP-dependent protein kinase type I-alpha
regulatory subunit protein, is involved in the modulation of protein kinase A activation.
Mutation of the gene is associated with Carney complex type 1, intracardiac myxoma,
and primary pigmented nodular adrenocortical disease type 1. Papillary thyroid carcinoma
is associated with a chromosomal translocation of this gene and the RET gene. A chromosomal
aberration affecting this gene and the RARA gene is associated with acute promyelocytic
leukemia.;