Acute Myeloid Leukemia Pathway

Preferred Label : Acute Myeloid Leukemia Pathway;

NCIt synonyms : AML Pathway;

NCIt related terms : Acute myeloid leukemia;

Alternative definition : KEGG: Two major types of genetic events are crucial for the molecular pathogenesis of acute myeloid leukemias (AML): activating mutations of signal transduction intermediates and alterations in myeloid transcription factors governing hematopoietic differentiation. Both aberrant and constitutive activation of signal transduction molecules are found in about 50% of primary AML bone marrow samples, and seem to contribute to the increased proliferation and apoptosis resistance. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Specific haematopoietic transcription factors are crucial for differentiation to particular lineages during normal differentiation, but are frequently disrupted in AML. Some mechanisms of disruption involve the effect of fusion proteins that are generated by chromosomal translocations on haematopoietic transcription factors. In other cases, the transcription factors themselves are mutated.;

KEGG ID : hsa05221;

Details

Origin ID

C91526;

UMLS CUI

C2984331;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukemia [ICD-O code]
- Acute myeloid leukemia [ORDO Disease]
- Acute myeloid leukemia [MedDRA LLT]
- Acute myeloid leukemia [HPO term]
- Acute myeloid leukemia [ICD-9 code]
- Acute myeloid leukemia (disorder) [SNOMED CT concept]
- Acute myeloid leukemia - category (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Leukemia, acute myeloid [OMIM Phenotype]
- Myeloid leukemia, acute [MedDRA LLT]
- Myeloid leukemia, acute [ICD-9 code]
- acute myeloid leukemia [DO Concept]
- acute myeloid leukemia [SNOMED Notion]
- acute myeloid leukemia [MedlinePlus Topic]
- leukemia, myeloid, acute [MeSH Descriptor]
- leukemia, myeloid, acute [MeSH concept]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Bcl2 Antagonist of Cell Death [NCIt concept]
- CCAAT/Enhancer Binding Protein Alpha [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Junction Plakoglobin [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Delta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Protein CBFA2T1 [NCIt concept]
- Protein PML [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Retinoic Acid Receptor Alpha [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- Runt-Related Transcription Factor 1 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase Pim-1 [NCIt concept]
- Serine/Threonine-Protein Kinase Pim-2 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Signal Transducer and Activator of Transcription 5A [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Transcription Factor PU.1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Zinc Finger and BTB Domain-Containing Protein 16 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CEBPA wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- EIF4EBP1 wt Allele [NCIt concept]
- FLT3 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- JUP wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PIM1 wt Allele [NCIt concept]
- PIM2 wt Allele [NCIt concept]
- PML wt Allele [NCIt concept]
- PPARD wt Allele [NCIt concept]
- RARA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- RUNX1 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- SPI1 wt Allele [NCIt concept]
- STAT3 wt Allele [NCIt concept]
- STAT5A wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- ZBTB16 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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