Junction Plakoglobin

Preferred Label : Junction Plakoglobin;

NCIt synonyms : Plakoglobin; Desmoplakin III; Gamma Catenin; Gamma-Catenin; JUP; DP III; Desmoplakin-3; Catenin Gamma;

NCIt definition : Junction plakoglobin (744 aa, 82 kDa) is encoded by the human JUP gene. This protein is involved in adherens junction assembly.;

NCIt note : Plakoglobin (gamma-Catenin) is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions. It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions. The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR. APC binds to and regulates beta- and gamma-Catenin. Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway. Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function. Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes.;

Details

Origin ID

C17524;

UMLS CUI

C1531215;

Currated CISMeF NLP mapping
- Plakoglobin [FMA entity]
- gamma catenin [MeSH Descriptor]
- gamma catenin [MeSH concept]
OMIM relation
- Junction plakoglobin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- JUP protein, human [MeSH concept]
- JUP protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cell Adhesion Molecule Gene [NCIt concept]
- JUP Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Desmosome [NCIt concept]
- Plasma Membrane [NCIt concept]
- Zonula Adherens [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Adherens Junction Formation Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907 [NCIt concept]

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