" /> RUNX1 wt Allele - CISMeF





Preferred Label : RUNX1 wt Allele;

NCIt synonyms : AML1 Oncogene Gene; AML1; Acute Myeloid Leukemia 1 Gene; CBFA2; PEBP2A2; PEBP2aB; Runt-Related Transcription Factor 1 wt Allele; AMLCR1;

NCIt definition : Human RUNX1 wild-type allele is located in the vicinity of 21q22.3 and is approximately 262 kb in length. This allele, which encodes Runt-related transcription factor 1 protein, is involved in both the modulation of transcription by RNA polymerase II and in hematopoiesis. Chronic myelogenous leukemia with or without blastic crisis, acute non-lymphocytic leukemia, T-cell acute lymphocytic leukemia, and myelodysplastic syndrome are all associated with complex chromosomal rearrangements of this gene.;

NCIt note : The translocation t(3;21)(q26;q22) of this gene and the EVI1 gene or the MDS1 gene are associated with myelodysplastic syndrome. The translocation t(1;21)(p36;q22) of this gene yields and the PRMD16 gene is associated with acute non-lymphocytic leukemia. The translocation t(12;21)(p12;q22) of this gene and the ETV6 gene is associated with B-cell acute lymphocytic leukemia (Atlas of Genetics and Cytogenetics in Hematology and Oncology).; The RUNX1 gene product binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters (GeneCards).;

GenBank Accession Number : NM_001754;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
11/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.